Evidence map›Paper›PMID 31018141›Full record

ArticleCell reports2019

The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Inga Schmidt, Renzo Mancuso, Wei-Ting Chen, Maya E Woodbury, Gyan Srivastava and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 552 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
552citing papers in PubMed, 2 pooled it
43.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

552 citing papers in PubMed, 2 syntheses or guidelines pooled it, 950 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. ApoE lipidation state directs immunometabolic reprogramming of human microglia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  15. Context-dependent roles of osteopontin in aging-related neurological disorders.The Journal of international medical research · 2026
    Review
  16. Review
  17. Article
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  20. Review

492 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Carlo Sala FrigerioVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address: carlo.salafrigerio@kuleuven.vib.be.
Leen WolfsVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Nicola FattorelliVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Nicola ThruppVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Iryna VoytyukVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Inga SchmidtVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Renzo MancusoVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Wei-Ting ChenVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Maya E WoodburyFoundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
Gyan SrivastavaFoundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
Thomas MöllerFoundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
Eloise HudryDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sudeshna DasDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Takaomi SaidoLaboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.
Eric KarranFoundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
Bradley HymanDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
V Hugh PerryUK Dementia Research Institute, University College London, London, UK; Centre for Biological Sciences, University of Southampton, Southampton, UK.
Mark FiersVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
Bart De StrooperVIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address: bart.destrooper@kuleuven.vib.be.
VIB-KU Leuven Center for Brain & Disease Research · BEAbbVie (United States) · USHarvard University · USUK Dementia Research Institute · GBRIKEN Center for Brain Science · JP

Funding

THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Synergy between amyloid and tau in Alzheimer's DiseaseRF1AG058674 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 2018 to 2018
$2.6M
APOEomic: Searching for APOE interacting risk factors using omics dataR01AG041232 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HUENTELMAN, MATT, MYERS, AMANDA J · 2013 to 2017
$1.7M
THE HUMAN BRAINOME:genome, transcriptome and proteome interaction in human cortexR01AG034504 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MYERS, AMANDA J · 2009 to 2012
$1.1M
NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG034504NIA NIH HHS R01 AG041232NIA NIH HHS RF1 AG058674Wellcome Trust
6 · The paper itself

Abstract

Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female App

Indexed as

Disease Models, AnimalAgingAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBiomarkersBrainFemaleHumansMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMice, TransgenicMicrogliaAmyloid beta-PeptidesAmyloid beta-Protein PrecursorBiomarkersPresenilinsAlzheimerapoeapp knock inARMin situ RNA hybridizationIRMmicrogliasingle cell RNA-seqsingle cell sequencing

Identifiers

PMID31018141
PMCPMC7340153
OpenAlexW2941510527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.