ArticleThe Journal of physiology2019
Bioenergetic basis for the increased fatigability with ageing.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Impact of total creatine and accessible phosphate pool on endurance exercise: implications for muscle fibers bioenergetic specificity and creatine supplementation.European journal of applied physiology · 2026Article
- Mechanisms underlying age-related changes in the human skeletal muscle bioenergetic system.European journal of applied physiology · 2026Article
- The effect of AMP deamination on skeletal muscle is stronger and more beneficial in extremely intense exercises to exhaustion and/or extremely stressing conditions.European journal of applied physiology · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Cross-bridge model-based quantification of muscle metabolite alterations leading to fatigue during all-out knee extension exercise.Frontiers in physiology · 2026Article
- Motor performance and aging in males and females.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025Review
- The influence of biological sex on the metabolic basis of skeletal muscle fatigue in vivo.The Journal of physiology · 2025Article
- Mechanisms for the age-related increase in fatigability of the elbow flexor muscles in healthy adults.Physiological reports · 2025Article
- A human skeletal muscle cross-bridge model to characterize the role of metabolite accumulation in muscle fatigue.Experimental physiology · 2025Article
- Skeletal Muscle Fatigue in Rats Is More Consistently Related to Increased Inorganic Phosphate Concentration Than Acidosis.Acta physiologica (Oxford, England) · 2025Article
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Impact of Long-Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function UsingJournal of cachexia, sarcopenia and muscle · 2025Article
- Are females getting more fatigable as they age?European journal of applied physiology · 2025Article
- Biochemical origin of (near-) linear curvature constant (W')-European journal of applied physiology · 2025Article
- Cumulative effects of HThe Journal of physiology · 2025Article
- PEuropean journal of applied physiology · 2025Article
- Delayed neuromuscular fatigue recovery unveils reduced fatigue tolerance in elderly following maximal intermittent exercise.European journal of applied physiology · 2024Article
- Phosphate is associated with frailty in older patients with chronic kidney disease not on dialysis.International urology and nephrology · 2024Article
- Metabolic dysfunction and the development of physical frailty: an aging war of attrition.GeroScience · 2024Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
key pointsThe mechanisms for the age-related increase in fatigability during dynamic exercise remain elusive. We tested whether age-related impairments in muscle oxidative capacity would result in a greater accumulation of fatigue causing metabolites, inorganic phosphate (P ABSTRACT: The present study aimed to determine whether the increased fatigability in old adults during dynamic exercise is associated with age-related differences in skeletal muscle bioenergetics. Phosphorus nuclear magnetic resonance spectroscopy was used to quantify concentrations of high-energy phosphates and pH in the knee extensors of seven young (22.7 ± 1.2 years; six women) and eight old adults (76.4 ± 6.0 years; seven women). Muscle oxidative capacity was measured from the phosphocreatine (PCr) recovery kinetics following a 24 s maximal voluntary isometric contraction. The fatiguing exercise consisted of 120 maximal velocity contractions (one contraction per 2 s) against a load equivalent to 20% of the maximal voluntary isometric contraction. The PCr recovery kinetics did not differ between young and old adults (0.023 ± 0.007 s
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.