Evidence map›Paper›PMID 31017936›Full record

ArticlePloS one2019

A modified diet does not ameliorate muscle pathology in a mouse model for Duchenne muscular dystrophy.

Ingrid E C Verhaart, Davy van de Vijver, Joke W Boertje-van der Meulen, Kayleigh Putker, Kevin Adamzek, Annemieke Aartsma-Rus, Maaike van Putten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ingrid E C VerhaartDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-7348-7989
Davy van de VijverDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Joke W Boertje-van der MeulenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Kayleigh PutkerDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Kevin AdamzekDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Annemieke Aartsma-RusDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Maaike van PuttenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is caused by a lack of dystrophin protein. Next to direct effects on the muscles, this has also metabolic consequences. The influence of nutrition on disease progression becomes more and more recognized. Protein intake by DMD patients may be insufficient to meet the increased demand of the constantly regenerating muscle fibers. This led to the hypothesis that improving protein uptake by the muscles could have therapeutic effects. The present study examined the effects of a modified diet, which composition might stimulate muscle growth, on disease pathology in the D2-mdx mouse model. D2-mdx males were fed with either a control diet or modified diet, containing high amounts of branched-chain amino acids, vitamin D3 and ursolic acid, for six weeks. Our study indicates that the modified diet could not ameliorate the muscle pathology. No effects on bodyweight or weight of individual muscles were observed. Neither did the diet affect severity of fibrosis or calcification of the muscles.

Indexed as

Amino Acids, Branched-ChainAnimalsCalcinosisCholecalciferolDietary ProteinsDisease Models, AnimalDystrophinFibrosisHumansMaleMiceMice, Inbred DBAMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, DuchenneRegenerationAmino Acids, Branched-Chainapo-dystrophin 1CholecalciferolDietary ProteinsDystrophinTriterpenesUrsolic Acid

Identifiers

PMID31017936
PMCPMC6481797
OpenAlexW2942353442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.