Evidence map›Paper›PMID 31017874›Full record

ArticleAging2019

Cell-autonomous and non-autonomous roles of

Hongning Wang, Phillip Webster, Lizhen Chen, Alfred L Fisher

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Non-autonomy of age-related morphological changes in thebioRxiv : the preprint server for biology · 2025
    Article
  5. A comprehensive approach, based on the use ofCurrent research in food science · 2025
    Article
  6. Article
  7. Article
  8. TSG Extends the Longevity ofAntioxidants (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Effect ofFoods (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to PromoteFrontiers in cell and developmental biology · 2021
    Article
  16. Article
  17. Expression of a FRET-based ATP Biosensor in themicroPublication biology · 2020
    Article
  18. Kynurenine pathway, NADExperimental gerontology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hongning Wang *Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, UTHSCSA, San Antonio, TX 78229, USA.
Phillip Webster *Division of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, UTHSCSA, San Antonio, TX 78229, USA.
Lizhen ChenCenter for Healthy Aging, UTHSCSA, San Antonio, TX 78229, USA.
Alfred L FisherDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Medicine, UTHSCSA, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · USAudie L. Murphy Memorial VA Hospital · USSouth Texas Veterans Health Care System · US

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Recruiting and Retaining URM StudentsR25GM095480 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OYAJOBI, BABATUNDE OLUKAYODE, WEISS, DAVID S · 2011 to 2021
$3.4M
Effects of insulin-like signaling, aging, and ubiquinone on C. elegans muscleR01AG044768 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FISHER, ALFRED L · 2012 to 2016
$1.6M
Regulation on of the AIRAP/aip-1 pathway by metabolic stressR01ES017761 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FISHER, ALFRED L · 2010 to 2014
$1.1M
Improving omega-3 fatty acid supplementation with microencapsulationR21NS102782 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FISHER, ALFRED L · 2018 to 2019
$480k
The Effects of Chronic mTOR Inhibition on Aging Muscle and Mitochondrial FunctionF31AG053054 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WEBSTER, PHILLIP JUSTIN · 2016 to 2017
$65k
NIA NIH HHS F31 AG053054NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG044768NIEHS NIH HHS R01 ES017761NIGMS NIH HHS R25 GM095480NINDS NIH HHS R21 NS102782
6 · The paper itself

Abstract

Sarcopenia, defined as the loss of skeletal muscle mass and strength, contributes to disability and health-related conditions with aging. In vitro studies indicate that age-related mitochondrial dysfunction could play a central role in the development and progression of sarcopenia, but because of limitations in the methods employed, how aging affects muscle mitochondrial function in vivo is not fully understood. We use muscle-targeted fluorescent proteins and the ratiometric ATP reporter, ATeam, to examine changes in muscle mitochondrial mass and morphology, and intracellular ATP levels in

Indexed as

AgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsLongevityMitochondria, MuscleMuscle, SkeletalNeuronsReceptor, InsulinCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDAF-2 protein, C elegansForkhead Transcription FactorsReceptor, Insulinagingdaf-16daf-2mitochondriamuscle

Identifiers

PMID31017874
PMCPMC6520005
OpenAlexW2940780180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.