Evidence map›Paper›PMID 31017816›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor.

Lizath M Aguiniga, Wenbin Yang, Ryan E Yaggie, Anthony J Schaeffer, David J Klumpp, MAPP Research Network Study Group

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Acyloxyacyl hydrolase regulates voiding activity.American journal of physiology. Renal physiology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lizath M AguinigaDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Wenbin YangDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Ryan E YaggieDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Anthony J SchaefferDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
David J KlumppDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-1237-8364
MAPP Research Network Study Group
Northwestern University · US

Funding

Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Mentoring For Success: Developing Fundamental Skills For Biomedical ResearchR25GM079300 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCGEE, RICHARD · 2007 to 2020
$6.6M
UTI Immune Modulation by LPS StructureF31AI106357 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AGUINIGA, LIZATH MONSERRATH · 2013 to 2017
$163k
NIAID NIH HHS F31 AI106357NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01 DK082342NIGMS NIH HHS R25 GM079300
6 · The paper itself

Abstract

Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCarboxylic Ester HydrolasesCorticosteroneCorticotropin-Releasing HormoneFemaleGene Expression RegulationHumansHypothalamo-Hypophyseal SystemMice, TransgenicParaventricular Hypothalamic NucleusPituitary-Adrenal SystemReceptors, Aryl HydrocarbonStress, Psychologicalacyloxyacyl hydrolaseAHR protein, humanBasic Helix-Loop-Helix ProteinsCarboxylic Ester HydrolasesCorticosteroneCorticotropin-Releasing HormoneReceptors, Aryl HydrocarbonAhRAOAHarachidonic acidCRFinterstitial cystitisstress

Identifiers

PMID31017816
PMCPMC6732428
OpenAlexW2942125456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.