Evidence map›Paper›PMID 31017810›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Mechanisms of sex differences in exercise capacity.

Marko Oydanich, Denis Babici, Jie Zhang, Nicole Rynecki, Dorothy E Vatner, Stephen F Vatner

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

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  13. Do Sex and Gender Have Separate Identities?Archives of sexual behavior · 2024
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  18. Ovariectomy aggravates the pathophysiological response to exertional heat stroke in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marko OydanichDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Denis BabiciDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Jie ZhangDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Nicole RyneckiDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Dorothy E VatnerDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Stephen F VatnerDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Rutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Skeletal Muscle Basis for Improved Exercise Endurance in RGS14 KOR01HL106511 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2011 to 2019
$3.8M
Intrinsic Vascular Smooth Muscle Cell StiffnessR01HL102472 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2010 to 2016
$2.5M
RGS 14 Disruption, Vascular Effects Leading to CardioprotectionR01HL124282 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2015 to 2018
$2.4M
Angiogenesis Protection Induced by sFRP3 Myocyte/Vascular Cross-TalkR01HL137405 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, DOROTHY EILEEN, VATNER, STEPHEN F · 2017 to 2020
$2.2M
Skeletal Muscle and Brown Adipose Mechanisms Mediating Cardiovascular Risk Factor Protection in RGS14 KOR01HL137368 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2017 to 2020
$2.1M
SFRP2, cell survival, and coronary vascular angiogenesisR01HL119464 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, DOROTHY EILEEN · 2013 to 2016
$1.8M
Vascular Protection in Hibernating WoodchucksR01HL130848 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2016 to 2019
$1.8M
Vevo 3100 High Resolution Imaging SystemS10OD025238 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2018 to 2018
$459k
INHIBITION OF ADENYLYL CYCLASE TYPE 5: HEALTHFUL AGING PROTECTIONR21AG053514 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, DOROTHY EILEEN · 2016 to 2017
$437k
NHLBI NIH HHS R01 HL102472NHLBI NIH HHS R01 HL106511NHLBI NIH HHS R01 HL119464NHLBI NIH HHS R01 HL124282NHLBI NIH HHS R01 HL130848NHLBI NIH HHS R01 HL137368NHLBI NIH HHS R01 HL137405NIA NIH HHS R21 AG053514NIH HHS S10 OD025238
6 · The paper itself

Abstract

Sex differences are an important component of National Institutes of Health rigor. The goal of this investigation was to test the hypothesis that female mice have greater exercise capacity than male mice, and that it is due to estrogen, nitric oxide, and myosin heavy chain expression. Female C57BL6/J wild-type mice exhibited greater (

Indexed as

Sex CharacteristicsAnimalsEstrogensExercise ToleranceFemaleMaleMice, Inbred C57BLNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOvariectomyPhysical Conditioning, AnimalSex FactorsEstrogensNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthaseestrogenexercise capacity-NAMEnitric oxidesex

Identifiers

PMID31017810
PMCPMC6734069
OpenAlexW2942330094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.