Evidence map›Paper›PMID 31017804›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.

Xinle Li, Daquan Liu, Jie Li, Shuang Yang, Jinfeng Xu, Hiroki Yokota, Ping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
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  7. Article
  8. The role of wnt signaling in diabetes-induced osteoporosis.Diabetology & metabolic syndrome · 2023
    Review
  9. Article
  10. Vascularized Tissue Organoids.Bioengineering (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinle LiDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Daquan LiuDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Jie LiDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Shuang YangDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Jinfeng XuDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Hiroki YokotaDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indiana, USA.
Ping ZhangDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Funding

MECHANICAL LOADING AND BONER01AR052144 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI YOKOTA, HIROKI · 2006 to 2018
$4.2M
NIAMS NIH HHS R01 AR052144
6 · The paper itself

Abstract

Osteoporosis is a major health problem, making bones fragile and susceptible to fracture. Previous works showed that mechanical loading stimulated bone formation and accelerated fracture healing. Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis. Two-week daily application of this novel loading (4 N, 10 Hz, 5 min/d) altered bone remodeling with an increase in Wnt3a. Spinal loading promoted osteoblast differentiation, endothelial progenitor cell migration, and tube formation and inhibited osteoclast formation, migration, and adhesion. A transient silencing of Wnt3a altered the observed loading effects. Spinal loading significantly increased bone mineral density, bone mineral content, and bone area per tissue area. The loaded OVX group showed a significant increase in the number of osteoblasts and reduction in osteoclast surface/bone surface. Though expression of osteoblastic genes was increased, the levels of osteoclastic genes were decreased by loading. Spinal loading elevated a microvascular volume as well as VEGF expression. Collectively, this study supports the notion that Wnt3a-mediated signaling involves in the effect of spinal loading on stimulating bone formation, inhibiting bone resorption, and promoting angiogenesis in OVX mice. It also suggests that Wnt3a might be a potential therapeutic target for osteoporosis treatment.-Li, X., Liu, D., Li, J., Yang, S., Xu, J., Yokota, H., Zhang, P. Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.

Indexed as

Bone RemodelingNeovascularization, PhysiologicWeight-BearingAnimalsBone DensityCells, CulturedFemaleHumansMiceMice, Inbred C57BLOsteoblastsOsteogenesisOsteoporosis, PostmenopausalOvariectomyVascular Endothelial Growth Factor AWnt3A ProteinVascular Endothelial Growth Factor AWnt3A ProteinWnt3a protein, mousebone formationbone resorptionneovascularizationOVXspinal load

Identifiers

PMID31017804
PMCPMC9272758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.