Evidence map›Paper›PMID 31017595›Full record

ReviewOrganic & biomolecular chemistry2019

Chemical composition of DNA-encoded libraries, past present and future.

Paige Dickson, Thomas Kodadek

Abstract readReview
In one paragraph

Review in Organic & biomolecular chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Expanding Bioactive Fragment Space with the Generated Database GDB-13s.Journal of chemical information and modeling · 2023
    Article
  6. Small-molecule discovery through DNA-encoded libraries.Nature reviews. Drug discovery · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paige DicksonDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. kodadek@scripps.edu.
Thomas Kodadek

Funding

Phenotypic screening using DNA-encoded librariesR01GM133041 · NIGMS · UNIVERSITY OF FLORIDA · PI KODADEK, THOMAS J. · 2018 to 2021
$3.2M
Discovery of Potent Proteasome Agonists to Improve ProteostasisR21AG054892 · NIA · SCRIPPS FLORIDA · PI KODADEK, THOMAS J. · 2017 to 2018
$523k
NIA NIH HHS R21 AG054892NIGMS NIH HHS R01 GM133041
6 · The paper itself

Abstract

DNA-encoded libraries represent an exciting and powerful modality for high-throughput screening. In this article, we highlight recent important advances in this field and also suggest some important directions that would make the technology even more powerful.

Indexed as

High-Throughput Screening AssaysCombinatorial Chemistry TechniquesDNASmall Molecule LibrariesDNASmall Molecule Libraries

Identifiers

PMID31017595
PMCPMC6520149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.