Evidence map›Paper›PMID 31017373›Full record

ArticleDepression and anxiety2019

Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: The 2019 Donald F. Klein Early Career Investigator Award Paper.

Suzanne Vrshek-Schallhorn, Catherine B Stroud, Leah D Doane, Susan Mineka, Richard E Zinbarg, Eva E Redei, Michelle G Craske, Emma K Adam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Suzanne Vrshek-SchallhornDepartment of Psychology, University of North Carolina, Greensboro, North Carolina.ORCID 0000-0003-2825-200X
Catherine B StroudDepartment of Psychology, Williams College, Williamstown, Massachusetts.
Leah D DoaneDepartment of Psychology, Arizona State University, Tempe, Arizona.
Susan MinekaDepartment of Psychology, Northwestern University, Evanston, Illinois.
Richard E ZinbargDepartment of Psychology, Northwestern University, Evanston, Illinois.
Eva E RedeiDepartment of Psychiatry & Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Michelle G CraskeDepartment of Psychology, University of California, Los Angeles, California.
Emma K AdamHuman Development and Social Policy Program, School of Education & Social Policy and Cells to Society Center, Institute for Policy Research, Northwestern University, Evanston, Illinois.
Northwestern University · USArizona State University · USJiamusi University · CNUniversity of California, Los Angeles · USUniversity of North Carolina at Greensboro · US

Funding

Common and Specific Risk Factors for Emotional DisordersR01MH065651 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2002 to 2011
$3.6M
Common and specific risk factors for emotoinal disordersR01MH065652 · NIMH · NORTHWESTERN UNIVERSITY · PI MINEKA, SUSAN, ZINBARG, RICHARD E · 2002 to 2011
$3.5M
Examining several possible causes of GxE non-replications in depressionF32MH091955 · NIMH · NORTHWESTERN UNIVERSITY · PI VRSHEK-SCHALLHORN, SUZANNE · 2010 to 2012
$153k
NIMH NIH HHS F32 MH091955NIMH NIH HHS R01 MH065651NIMH NIH HHS R01 MH065652
6 · The paper itself

Abstract

backgroundThe serotonin system and hypothalamic pituitary-adrenal (HPA)-axis are each implicated in the pathway to depression; human and animal research support these systems' cross-talk. Our work implicates a 5-variant additive serotoninergic multilocus genetic profile score (MGPS) and separately the cortisol awakening response (CAR) in the prospective prediction of depression; other work has shown that the serotonin transporter polymorphism 5HTTLPR predicts CAR and interacts with the CAR to predict depression.

methodsWe tested the hypothesis that a 6-variant MGPS (original plus 5HTTLPR) would interact with CAR to predict prospective depressive episode onsets in 201 emerging adults using four annual follow-up interviews. We also tested whether MGPS predicted CAR. We attempted replication of significant findings in a sample of 77 early adolescents predicting depression symptoms.

resultsIn sample 1, MGPS did not significantly predict CAR. MGPS interacted with CAR to predict depressive episodes; CAR slopes for depression steepened as MGPS increased, for risk or protection. No single variant accounted for results, though CAR's interactions with 5HTTLPR and the original MGPS were both significant. In sample 2, the 6-variant MGPS significantly interacted with CAR to predict depression symptoms.

conclusionsHigher serotonergic MGPS appears to sensitize individuals to CAR level-for better and worse-in predicting depression.

Indexed as

Awards and PrizesAdolescentDepressionDepressive DisorderFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPolymorphism, GeneticProspective StudiesRisk FactorsSerotoninSerotonin Plasma Membrane Transport ProteinsHydrocortisoneSerotoninSerotonin Plasma Membrane Transport Proteinscortisol awakening responsedepressionemerging adultsmultilocus genetic profile scoreserotonin

Identifiers

PMID31017373
PMCPMC8237709
OpenAlexW2941701804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.