ArticleThe American journal of tropical medicine and hygiene2019
Beyond Blood Smears: Qualification of
Open access · bronzeAbstract readValidation Study
In one paragraph
Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial.Nature medicine · 2025Trial
- Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials.The Lancet. Infectious diseases · 2024Trial
- Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Trial
- Trial
- Molecular surveillance of Falciparum malaria in Rwanda: Shifts in parasite prevalence and risk factors between the 2014-15 and 2019-20 Rwanda Demographics and Health Surveys.medRxiv : the preprint server for health sciences · 2026Article
- Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans.Nature communications · 2025Article
- Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.Science (New York, N.Y.) · 2025Article
- Potent AMA1-specific human monoclonal antibody against Plasmodium vivax Pre-erythrocytic and Blood Stages.Nature communications · 2024Article
- Review
- A conserved Plasmodium nuclear protein is critical for late liver stage development.Communications biology · 2024Article
- Article
- Article
- A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion.EMBO molecular medicine · 2024Article
- Enhancing malaria detection in resource-limited areas: A high-performance colorimetric LAMP assay for Plasmodium falciparum screening.PloS one · 2024Article
- Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research.Malaria journal · 2023Article
- The 18S rRNA genes of Haemoproteus (Haemosporida, Apicomplexa) parasites from European songbirds with remarks on improved parasite diagnostics.Malaria journal · 2023Article
- The Dantu blood group prevents parasite growtheLife · 2023Article
- Article
- Multi-arm covariate-adaptive randomization.Science China. Mathematics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 10 institutions in 1 country.
Annette M SeilieDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Ming ChangDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Amelia E HanronDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Zachary P BillmanDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Brad C StoneDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Kevin ZhouDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Tayla M OlsenDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Glenda DazaDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Jose OrtegaDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Kurtis R CruzDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Nahum SmithDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Sara A HealyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Jillian NealLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Carolyn K WallisDepartment of Laboratory Medicine, Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, Washington.
Lisa SheltonCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Tracie VonGoedert MankowskiCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Sharon Wong-MaddenLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Sebastian A MikolajczakCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Ashley M VaughanCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Stefan H I KappeCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Matt FishbaugherCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Will BetzCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Mark KennedyCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Jen C C HumeLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Angela K TalleyCenter for Global Infectious Disease Research, Seattle Children's Research Institute (formerly the Center for Infectious Disease Research), Seattle, Washington.
Stephen L HoffmanSanaria, Inc., Rockville, Maryland.
Sumana ChakravartySanaria, Inc., Rockville, Maryland.
B Kim Lee SimSanaria, Inc., Rockville, Maryland.
Thomas L RichieSanaria, Inc., Rockville, Maryland.
Anna WaldDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.
Christopher V PloweDuke Global Health Institute, Duke University, Durham, North Carolina.
Kirsten E LykeCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Matthew AdamsCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Gary A FahleMicrobiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Elliot P CowanPartners in Diagnostics, Rockville, Maryland.
Patrick E DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
James G KublinSeattle Malaria Clinical Trials Center, Fred Hutch Cancer Research Center, Seattle, Washington.
Sean C MurphyDepartment of Microbiology, University of Washington, Seattle, Washington.
University of Washington · USCenter for Infectious Disease Research · USInfectious Disease Research Institute · USNational Institutes of Health · USSanaria · USUniversity of Maryland, Baltimore · USDuke University · USFred Hutch Cancer Center · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health Clinical Center · US
Funding
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9MPre-erythrocytic malaria vaccines: Discovery and Clinical DevelopmentZIAAI001135 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2010 to 2025
$6.4MPfSPZ Challenge with Chemoprophylaxis: Phase 1 Trial to Assess Liver Stage DrugU01AI109700 · NIAID · SANARIA, INC. · PI DUFFY, PATRICK E, HOFFMAN, STEPHEN LEV · 2013 to 2015
$779kNIAID NIH HHS P30 AI027757NIAID NIH HHS U01 AI109700
Abstract
18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and
Indexed as
BiomarkersHumansMalariaMultiplex Polymerase Chain ReactionPlasmodiumReal-Time Polymerase Chain ReactionReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, ProtozoanRNA, Ribosomal, 18SBiomarkersRNA, ProtozoanRNA, Ribosomal, 18S
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.