Evidence map›Paper›PMID 31017046›Full record

ArticleStem cells and development2019

MicroRNA-200c Attenuates Periodontitis by Modulating Proinflammatory and Osteoclastogenic Mediators.

Adil Akkouch, Min Zhu, Miguel Romero-Bustillos, Steven Eliason, Fang Qian, Aliasger K Salem, Brad A Amendt, Liu Hong

Open access · greenAbstract read
In one paragraph

Article in Stem cells and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. International journal of molecular sciences · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. MicroRNAs: The Missing Link between Hypertension and Periodontitis?International journal of molecular sciences · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Exploring microRNAs in craniofacial regenerative medicine.Biochemical Society transactions · 2023
    Review
  17. Review
  18. Article
  19. Plasmid encodingNanomedicine (London, England) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Adil Akkouch1Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Min Zhu1Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Miguel Romero-Bustillos2Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Steven Eliason3Center for Craniofacial Anomalies Research, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.
Fang Qian1Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Aliasger K Salem5Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa.
Brad A Amendt1Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Liu Hong1Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
University of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Oral and Craniofacial Bone Regeneration using MicroRNA ModulationR01DE026433 · NIDCR · UNIVERSITY OF IOWA · PI AMENDT, BRAD A, HONG, LIU · 2017 to 2021
$1.8M
University of Iowa Institutional Training Program in Oral Health ResearchR90DE024296 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$1.8M
A microRNA-based Approach for Periodontitis-associated Bone LossR21DE024799 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2015 to 2016
$417k
A microRNA-based Approach for Bone RegenerationR21DE025328 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2016 to 2017
$410k
NIDCR NIH HHS R01 DE026433NIDCR NIH HHS R21 DE024799NIDCR NIH HHS R21 DE025328NIDCR NIH HHS R90 DE024296
6 · The paper itself

Abstract

This study tested whether microRNA

Indexed as

Alveolar Bone LossAnimalsCells, CulturedGene Expression RegulationHumansInflammationInflammation MediatorsLipopolysaccharidesMaleMicroRNAsOsteogenesisPeriodontitisRatsRats, Sprague-DawleyInflammation MediatorsLipopolysaccharidesMicroRNAsMIRN200 microRNA, humanalveolar bone lossmicroRNAperiodontitispolyethylenimineproinflammatory

Identifiers

PMID31017046
PMCPMC6661922
OpenAlexW2942031141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.