Evidence map›Paper›PMID 31017036›Full record

ArticleJournal of the American Heart Association2019

Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study.

Ian J Neeland, Sebastiaan C Boone, Dennis O Mook-Kanamori, Colby Ayers, Roelof A J Smit, Ioanna Tzoulaki, Ibrahim Karaman, Claire Boulange, Dhananjay Vaidya, Naresh Punjabi and 8 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Ian J Neeland1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
Sebastiaan C Boone2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
Dennis O Mook-Kanamori2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
Colby Ayers4 Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas TX.
Roelof A J Smit2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
Ioanna Tzoulaki5 Department of Epidemiology and Biostatistics Imperial College London London United Kingdom.
Ibrahim Karaman5 Department of Epidemiology and Biostatistics Imperial College London London United Kingdom.
Claire Boulange6 Metabometrix Ltd Imperial College London London United Kingdom.
Dhananjay Vaidya7 Department of Medicine Johns Hopkins University Baltimore MD.
Naresh Punjabi7 Department of Medicine Johns Hopkins University Baltimore MD.
Matthew Allison8 Department of Family Medicine and Public Health University of California San Diego La Jolla CA.
David M Herrington9 Department of Medicine Wake Forest University Winston Salem NC.
J Wouter Jukema10 Department of Cardiology Leiden University Medical Center Leiden the Netherlands.
Frits R Rosendaal2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
Hildo J Lamb11 Department of Radiology Leiden University Medical Center Leiden the Netherlands.
Ko Willems van Dijk12 Department of Human Genetics Leiden University Medical Center Leiden the Netherlands.
Philip Greenland15 Department of Preventive Medicine Northwestern University Chicago IL.
Renée de Mutsert2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
Leiden University Medical Center · NLImperial College London · GBJohns Hopkins University · USThe University of Texas Southwestern Medical Center · USNorthwestern University · USUniversity of California, San Diego · USWake Forest University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6M
Genomic and Proteomic Architecture of AtherosclerosisR01HL111362 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2012 to 2021
$17.2M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95160 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL · 2007 to 2015
$7.7M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC95164 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG · 2007 to 2015
$7.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEA, STEVEN · 2007 to 2014
$6.4M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95165 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BURKE, GREGORY L · 2007 to 2014
$6.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95163 · NHLBI · UNIVERSITY OF MINNESOTA · PI FOLSOM, AARON R · 2007 to 2014
$6.1M
TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)N01HC95162 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY · 2007 to 2015
$6.0M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC95166 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 2007 to 2014
$4.0M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL111362NHLBI NIH HHS R01 HL133932NIDDK NIH HHS K23 DK106520NIH HHS HHSN263201500003I
6 · The paper itself

Abstract

Background Identifying associations between serum metabolites and visceral adipose tissue ( VAT ) could provide novel biomarkers of VAT and insights into the pathogenesis of obesity-related diseases. We aimed to discover and replicate metabolites reflecting pathways related to VAT . Methods and Results Associations between fasting serum metabolites and VAT area (by computed tomography or magnetic resonance imaging) were assessed with cross-sectional linear regression of individual-level data from participants in MESA (Multi-Ethnic Study of Atherosclerosis; discovery, N=1103) and the NEO (Netherlands Epidemiology of Obesity) study (replication, N=2537). Untargeted

Indexed as

MetabolomicsAgedAged, 80 and overAmino AcidsAmino Acids, Branched-ChainCholesterol, HDLCholesterol, LDLFemaleGluconeogenesisGlutamineGlycolysisHumansIntra-Abdominal FatLactic AcidLinear ModelsMagnetic Resonance ImagingAmino AcidsAmino Acids, Branched-ChainCholesterol, HDLCholesterol, LDLGlutamineLactic AcidTriglyceridesadipose tissuecohortmetabolitemetabolomicsobesityvisceral adipose tissue

Identifiers

PMID31017036
PMCPMC6512086
OpenAlexW2941154832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.