Evidence map›Paper›PMID 31016908›Full record

ArticleYonsei medical journal2019

Effect of Sperm DNA Fragmentation on Embryo Quality in Normal Responder Women in In Vitro Fertilization and Intracytoplasmic Sperm Injection.

Su Mi Kim, Seul Ki Kim, Byung Chul Jee, Seok Hyun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Su Mi KimDepartment of Obstetrics and Gynecology, Chungbuk National University Hospital, Cheongju, Korea.ORCID https://orcid.org/0000-0002-5236-7184
Seul Ki KimDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1647-6711
Byung Chul JeeDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2289-6090
Seok Hyun KimDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0649-3224
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the associations between sperm DNA fragmentation (SDF) and embryo formation rate in normal responder women to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). MATERIALS AND

methodsFifty-three consecutive, fresh IVF/ICSI cycles performed from 2014 to 2017 were selected. All women were normal responders (4 to 14 mature oocytes were retrieved) and at least one normally fertilized oocyte with two pronuclei was obtained in all cycles. Semen was collected on the day of oocyte retrieval, and SDF levels were measured by sperm chromatin dispersion test (Halosperm assay). At day 3 after insemination, embryo quality was evaluated by morphologic criteria and categorized as A/B/C/D. Top quality embryo were defined as grade A embryos with seven cells or more.

resultsSDF levels showed a positive linear correlation with the male's age (r=0.307,

conclusionIn normal responder women, high SDF level resulted in low day 3 embryo formation rates. Our results suggest a paternal effect on embryo quality in IVF/ICSI cycles.

Indexed as

DNA FragmentationFertilization in VitroSperm Injections, IntracytoplasmicAdultEmbryo, MammalianFemaleHumansMaleSpermatozoaembryo qualityIn vitro fertilizationsperm chromatin dispersion testsperm DNA fragmentation

Identifiers

PMID31016908
PMCPMC6479125
OpenAlexW2941484446

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.