Evidence map›Paper›PMID 31016881›Full record

ArticleCancer medicine2019

Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma.

Andreea G Andronesi, Alina D Tanase, Bogdan M Sorohan, Oana G Craciun, Laura Stefan, Zsofia Varady, Lavinia Lipan, Bogdan Obrisca, Alexandra Truica, Gener Ismail

Abstract read
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. [Risk factors for acute kidney injury after hematopoietic stem cell transplantation in children: a retrospective study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreea G AndronesiNephrology Department, Fundeni Clinical Institute, Bucharest, Romania.ORCID 0000-0002-5590-7879
Alina D TanaseBone Marrow Transplant Department, Fundeni Clinical Institute, Bucharest, Romania.
Bogdan M SorohanNephrology Department, Fundeni Clinical Institute, Bucharest, Romania.ORCID 0000-0003-3574-4635
Oana G CraciunBone Marrow Transplant Department, Fundeni Clinical Institute, Bucharest, Romania.
Laura StefanBone Marrow Transplant Department, Fundeni Clinical Institute, Bucharest, Romania.
Zsofia VaradyBone Marrow Transplant Department, Fundeni Clinical Institute, Bucharest, Romania.
Lavinia LipanBone Marrow Transplant Department, Fundeni Clinical Institute, Bucharest, Romania.
Bogdan ObriscaNephrology Department, Fundeni Clinical Institute, Bucharest, Romania.ORCID 0000-0003-4796-4950
Alexandra TruicaCarol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Gener IsmailNephrology Department, Fundeni Clinical Institute, Bucharest, Romania.ORCID 0000-0003-3306-189X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) is unknown. We evaluated the incidence, severity, and risk factors for AKI within the first 30 days after autologous stem cell transplantation (ASCT) for MM. We prospectively followed 185 consecutive patients with MM, without chronic renal replacement therapy, who underwent ASCT; 12.5% of patients had MM-associated amyloidosis. AKI occurred in 19 (10.3%) patients, 8 ± 3 days after ASCT, with 18 patients (9.7%) stage 1 and one patient (0.6%) stage 2 AKI. The development of AKI was not associated with reduced overall survival and recovery of kidney function was evident in 68.4% of patients at 3 months. In Cox regression analysis, preexisting-chronic kidney disease (HR 7.01, CI 95% 2.04-24.09; P = 0.002), serum beta2 microglobulin (HR 3.05, CI 95% 1.10-8.44; P = 0.03), and mucositis grade 3/4 (HR 1.29, CI 95% 1.08-1.53; P = 0.003) were independent risk factors for AKI. Our results suggest that AKI occurs with low incidence and reduced severity after ASCT for MM. Prophylactic measures in patients with preexisting-kidney failure may further reduce this risk.

Indexed as

Acute Kidney InjuryAdultAgedComorbidityDisease SusceptibilityFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansIncidenceMaleMiddle AgedMultiple MyelomaProportional Hazards ModelsRisk FactorsTransplantation, Autologousacute kidney injurymultiple myelomastem cell transplant

Identifiers

PMID31016881
PMCPMC6558584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.