Evidence map›Paper›PMID 31016755›Full record

ArticleExperimental physiology2019

Insufficient sleep is associated with a pro-atherogenic circulating microRNA signature.

Jamie G Hijmans, Ma'ayan Levy, Vinicius Garcia, Grace M Lincenberg, Kyle J Diehl, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  15. Effects of sleep deprivation on coronary heart disease.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Review
  16. Article
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  19. Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jamie G HijmansIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.ORCID 0000-0003-1813-8756
Ma'ayan LevyIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Vinicius GarciaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Grace M LincenbergIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Kyle J DiehlIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.
Brian L StaufferIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.ORCID 0000-0003-3418-7750
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA.ORCID 0000-0001-9372-5083
University of Colorado Boulder · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
HIV-1, Insufficient Sleep and Vascular Endothelial DysfunctionR01HL131458 · NHLBI · UNIVERSITY OF COLORADO · PI CONNICK, ELIZABETH, DESOUZA, CHRISTOPHER A · 2016 to 2019
$3.0M
Sleep and Blood Pressure-Related Endothelial AbnormalitiesR01HL135598 · NHLBI · UNIVERSITY OF COLORADO · PI DESOUZA, CHRISTOPHER A, STAUFFER, BRIAN L · 2017 to 2020
$3.0M
NCI CLINICAL INVESTIGATOR AWARD PROGRAMK08CA001082 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI KIM, SINIL · 1985 to 1987
–
NCATS NIH HHS TR001082NCATS NIH HHS UL1 TR001082NHLBI NIH HHS R01 HL131458NHLBI NIH HHS R01 HL135598
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of the study Is habitual short sleep associated with altered circulating levels of specific inflammation- and vascular-related microRNAs? What is the main finding and its importance? Circulating levels of miR-125a, miR-126 and miR-146a were significantly lower in the short sleep compared with the normal sleep group. Altered circulating profiles of these vascular-related microRNAs have been linked to vascular inflammation, dysfunction and increased cardiovascular disease events. Sleep-related changes in these microRNAs are consistent with, and might play a role in, the aberrant vascular physiology and increased vascular risk associated with short sleep. ABSTRACT: Habitual short sleep duration (<7 h night

Indexed as

AtherosclerosisBiomarkersCirculating MicroRNAFemaleHumansInflammationMaleMiddle AgedSleepSleep DeprivationBiomarkersCirculating MicroRNAendothelialinflammationmiRNAshort sleep

Identifiers

PMID31016755
PMCPMC6544492
OpenAlexW2942377777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.