ArticleClinical rheumatology2019
Evaluation of vastus lateralis architecture and strength of knee extensors in middle-aged and older individuals with knee osteoarthritis.
Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06226792 (Muscle Architecture in Ankylosing Spondylitis and Its Relationship With Clinical Parameters), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Architecture in Ankylosing Spondylitis and Its Relationship With Clinical Parameters
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Disease severity affects knee range of motion but not strength deficits in knee osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Association between imbalanced lower extremity muscle quality and the development of knee osteoarthritis: a Systematic Review and meta-analysis.Frontiers in physiology · 2026Pooled it
- The course of knee extensor strength after total knee arthroplasty: a systematic review with meta-analysis and -regression.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Reductions of cardiovascular and metabolic risk factors after a 14-week periodized training model in patients with knee osteoarthritis: a randomized controlled trial.Clinical rheumatology · 2021Trial
- Distribution of lower limb muscles may be associated with the progression of knee osteoarthritis and sarcopenia: a cross-sectional study.Frontiers in medicine · 2026Article
- Quantitative ultrasound assessment of gastrocnemius muscle changes in patients with knee osteoarthritis.The Journal of international medical research · 2026Article
- Assessment of vastus medialis muscle quality in knee osteoarthritis using ultrashort echo time magnetization transfer MR imaging.Skeletal radiology · 2025Article
- Knee Health Is a Major Determinant of Mobility Across the Healthspan.Journal of functional morphology and kinesiology · 2025Review
- Article
- Thigh muscle features in female patients with severe knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Differences in ankle and knee muscle architecture and plantar pressure distribution among women with knee osteoarthritis.Journal of foot and ankle research · 2024Article
- Comparison of the asymmetries in muscle mass, biomechanical property and muscle activation asymmetry of quadriceps femoris between patients with unilateral and bilateral knee osteoarthritis.Frontiers in physiology · 2023Article
- Article
- Telerehabilitation for Knee Osteoarthritis in Brazil: A Feasibility Study.International journal of telerehabilitation · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate any differences in muscle architecture (fascicle angle, fascicle length, and muscle thickness) and muscle strength in people of different ages with and without knee osteoarthritis (OA).
methodsThis is a cross-sectional study conducted with 40 individuals with and 40 without knee OA. Four groups were analyzed, middle-aged OA group (KL II/III) aged 40-50 years (n = 20), middle-aged healthy (H) group aged 40-50 years (n = 20), older OA group (KL II/III) aged 70 years and over (n = 20), and older H group, aged 70 years and over (n = 20). Outcomes analyzed were isometric and isokinetic peak torque of knee extensors, level of physical activity, self-reported pain level, and vastus lateralis fascicle length, fascicle angle, and muscle thickness assessed by ultrasound. One-way ANOVA was used to identify differences between groups, followed by the Tukey post hoc test.
resultsThere were no differences between the middle-aged OA group and older H group for any variables. The older OA group presented the smallest muscle architecture parameters and worst isometric and concentric peak torques compared to the other three groups (p < 0.001). In contrast, the middle-aged H group presented the largest muscle architecture parameters and was the strongest group compared to the others (p < 0.001).
conclusionsThe presence of knee OA is associated with early muscular changes and seems to intensify these thigh changes that are similar to the effects of the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.