ReviewJournal of microbiology (Seoul, Korea)2019
EAST1 toxin: An enigmatic molecule associated with sporadic episodes of diarrhea in humans and animals.
Review in Journal of microbiology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Hybrid enteric-extraintestinal lineages in astA-positive Escherichia coli: Molecular characterization and high-risk MDR clones in Neonatal Calves.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- EnteroaggregativeEcoSal Plus · 2025Review
- Poultry pathogenicity, antimicrobial resistance, and one health genomic characterization of ST83 Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Population Structure, Genomic Features, and Antibiotic Resistance of Avian PathogenicMicroorganisms · 2025Article
- Review
- Prevalence, sequence diversity, and amplification of an IS-associated enterotoxin gene,Frontiers in microbiology · 2025Article
- Genomic characterization of multidrug-resistantFrontiers in microbiology · 2025Article
- Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.BMC veterinary research · 2024Article
- Characteristics, Whole-Genome Sequencing and Pathogenicity Analysis ofMicroorganisms · 2023Article
- Genomic traits of multidrug resistant enterotoxigenicFrontiers in microbiology · 2023Article
- An exploration of alginate oligosaccharides modulating intestinal inflammatory networksFrontiers in microbiology · 2023Review
- Identification and Genomic Characterization ofPathogens (Basel, Switzerland) · 2022Article
- Prevalence of Virulence Genes AmongJournal of veterinary research · 2022Article
- Genome-Based Assessment of Antimicrobial Resistance and Virulence Potential of Isolates of Non-Pullorum/Gallinarum Salmonella Serovars Recovered from Dead Poultry in China.Microbiology spectrum · 2022Article
- Characterization of virulence determinants and phylogenetic background of multiple and extensively drug resistant Escherichia coli isolated from different clinical sources in Egypt.Applied microbiology and biotechnology · 2022Article
- Virulence Characteristics, Antibiotic Resistance Patterns and Molecular Typing of Enteropathogenic ProducingInfection and drug resistance · 2022Article
- Genomic Analysis of a Highly Virulent NDM-1-ProducingFrontiers in microbiology · 2022Article
- Article
- Pig vaccination strategies based on enterotoxigenic Escherichia coli toxins.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Post-weaning diarrhea in pigs weaned without medicinal zinc: risk factors, pathogen dynamics, and association to growth rate.Porcine health management · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EAST1 is produced by a subset of enteroaggregative Escherichia coli strains. This toxin is a 38-amino acid peptide of 4100 Da. It shares 50% homology with the enterotoxic domain of STa and interacts with the same receptor. The mechanism of action of EAST1is proposed to be identical to that of STa eliciting a cGMP increase. EAST1 is associated with diarrheal disease in Man and various animal species including cattle and swine. Nevertheless, as EAST1-positive strains as well as culture supernatants did not provoke unequivocally diarrhea either in animal models or in human volunteers, the role of this toxin in disease is today still debated. This review intent is to examine the role of EAST1 toxin in diarrheal illnesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.