Evidence map›Paper›PMID 31016507›Full record

SynthesisCurrent medical science2019

Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials.

Jun Liu, Guo-Bing Wan, Ming-Shi Huang, George Agyapong, Tian-le Zou, Xue-Ying Zhang, Yen-Wenn Liu, Yi-Qing Song, Ying-Chieh Tsai, Xue-Jun Kong

Erratum issuedAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. CouldJournal of clinical medicine · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jun LiuHarvard Medical School, Boston, 02115, USA.
Guo-Bing WanWomen and Children's Hospital, Shenzhen, 518052, China.
Ming-Shi HuangWomen and Children's Hospital, Shenzhen, 518052, China.
George AgyapongHarvard Medical School, Boston, 02115, USA.
Tian-le ZouNew York University, Buffalo, 14214, USA.
Xue-Ying ZhangIcahn School of Medicine at Mount Sinai, New York City, 10029, USA.
Yen-Wenn LiuNational Yang Ming University, Taipei, 112, China.
Yi-Qing SongIndiana University, Indianapolis, 46202, USA.
Ying-Chieh TsaiNational Yang Ming University, Taipei, 112, China.
Xue-Jun KongMassachusetts General Hospital, Charlestown, 02129, USA. xkong1@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.

Indexed as

Autism Spectrum DisorderBehavioral SymptomsClinical Trials as TopicGastrointestinal DiseasesGastrointestinal TractHumansProbioticsautism spectrum disorderprobioticssystematic review

Identifiers

PMID31016507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.