Evidence map›Paper›PMID 31016455›Full record

Observational studyObesity surgery2019

The HAALT Non-invasive Scoring System for NAFLD in Obesity.

Harsh Sheth, Samir Bagasrawala, Mita Shah, Rais Ansari, A Olithselvan, Muffazal Lakdawala

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04553796 (Assessment of Nonalcoholic Fatty Liver Disease in Diabetic and Prediabetic Patients Using Noninvasive Methods.), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04553796 unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Nonalcoholic Fatty Liver Disease in Diabetic and Prediabetic Patients Using Noninvasive Methods.

TypeobservationalSponsorAssiut UniversityRan2021 to 2022Enrolled150ConditionsNon Alcoholic Fatty LiverArmsfibroscan
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Harsh ShethInstitute of Minimally Invasive Surgical Sciences and Research, Saifee Hospital, 15/17 Maharshi Karve Marg, Opera House, Mumbai, 400004, India. harsh86sheth@gmail.com.ORCID 0000-0002-5591-717X
Samir BagasrawalaInstitute of Minimally Invasive Surgical Sciences and Research, Saifee Hospital, 15/17 Maharshi Karve Marg, Opera House, Mumbai, 400004, India.
Mita ShahDepartment of Pathology, Saifee Hospital, 15/17 Maharshi Karve Marg, Opera House, Mumbai, 400004, India.
Rais AnsariInstitute of Minimally Invasive Surgical Sciences and Research, Saifee Hospital, 15/17 Maharshi Karve Marg, Opera House, Mumbai, 400004, India.
A OlithselvanDepartment of Hepatology, Yashoda Hospital, S. P Road, Secunderabad, 500003, India.
Muffazal LakdawalaInstitute of Minimally Invasive Surgical Sciences and Research, Saifee Hospital, 15/17 Maharshi Karve Marg, Opera House, Mumbai, 400004, India.
Saifee Hospital · INYashoda Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of NAFLD increases in obese diabetics. Accurate diagnosis of NAFLD requires invasive liver biopsies, which is costly, and time consuming and labor intensive. Currently, there is a lack of non-invasive diagnostic methods to identify those with NASH, in obese Indians.

objectivesTo develop an accurate non-invasive scoring system using clinical and biochemical parameters to predict the risk of developing non-alcoholic steatohepatitis (NASH).

methodsClinical and biochemical parameters were recorded pre-operatively from 290 patients who were posted for bariatric/metabolic surgery, between September 2017 and October 2018 and compared with the result of intra-operative liver biopsy NAFLD activity scores (NAS).

resultsThe mean weight and BMI of the patients were 120.3 ± 24.6 and 45.5 ± 7.8 respectively. In the final histopathological examination, 196/290 (67.6%) had simple steatosis, 92/290 (31.7%) had NASH, and 2/290 (0.007%) had cirrhosis. Binary logistic regression analysis of multiple independent predictors yielded five independent factors that were statistically significant (HbA1c, AST, ALT, liver span on USG, and serum triglycerides). These were used to create a scoring system, with a range of scores from 0 to 6, with maximum predictability at a score of 6. Patients with scores of ≧ 3 were at high risk of NASH diagnosis. The sensitivity of this scoring system was 85.87% and diagnostic accuracy was 75.35%.

conclusionsOur study not only confirms the significant association of NAFLD with obesity but also outlines a simple non-invasive scoring system to identify obese individuals at high risk for NASH.

Indexed as

Models, StatisticalAdultBariatric SurgeryBiopsyDiabetes Mellitus, Type 2FemaleHumansLiver CirrhosisMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityObesity, MorbidPredictive Value of TestsPrognosisReproducibility of ResultsBariatric surgeryHepatosteatosisLiver biopsyMetabolic syndromeMorbid obesityNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisObesityPredictive modelScoring systemType 2 diabetes mellitus

Identifiers

PMID31016455
OpenAlexW2940877042

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.