ArticleEuropean journal of epidemiology2020
Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study.
Article in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04680338 (Early Detection of Silent Myocardial Ischemia and Cardiac Dysfunction in Asymptomatic Individuals With Increased Coronary Artery Calcium Scores), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Silent Myocardial Ischemia and Cardiac Dysfunction in Asymptomatic Individuals With Increased Coronary Artery Calcium Scores
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Population-Based Screening Using Low-Dose Chest Computed Tomography: A Systematic Review of Health Economic Evaluations.PharmacoEconomics · 2023Pooled it
- Repeatability of AI-quantified incidental findings on lung cancer screening CT scans in the NELSON trial.European radiology · 2026Article
- Serum T50 is not independently associated with coronary artery calcification in early chronic kidney disease.Clinical kidney journal · 2026Article
- Biomarkers in plasma and extracellular vesicles for early detection of asymptomatic ischemic heart disease: a retrospective case-control study.Cardiovascular diagnosis and therapy · 2026Article
- Clinical Research Progress in the Treatment and Prognosis of Comorbid Coronary Heart Disease and Lung Cancer.Reviews in cardiovascular medicine · 2026Review
- Association Between Emphysema and Coronary Artery Calcium on Low-Dose CT in Urban Chinese Adults: Does Lifestyle Matter?Healthcare (Basel, Switzerland) · 2026Article
- Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers.Journal of Alzheimer's disease : JAD · 2026Article
- Repeatability of AI-based, automatic measurement of vertebral and cardiovascular imaging biomarkers in low-dose chest CT: the ImaLife cohort.European radiology · 2025Article
- Towards a more realistic anthropomorphic chest phantom using 3D-printed and cork-integrated components.Medical physics · 2025Article
- Reference formulas for chest CT-derived lobar volumes in the lung-healthy general population.European radiology · 2025Article
- Model-Based Cost-Utility Analysis of Combined Low-Dose Computed Tomography Screening for Lung Cancer, Chronic Obstructive Pulmonary Disease, and Cardiovascular Disease.JTO clinical and research reports · 2025Article
- Multi-omics model is an effective means to diagnose benign and malignant pulmonary nodules.Clinics (Sao Paulo, Brazil) · 2025Article
- Article
- Beyond lung cancer screening, an opportunity for early detection of chronic obstructive pulmonary disease and cardiovascular diseases.JNCI cancer spectrum · 2024Article
- Willingness to participate in combination screening for lung cancer, chronic obstructive pulmonary disease and cardiovascular disease in four European countries.European radiology · 2024Article
- Who is at risk of lung nodules on low-dose CT in a Western country? A population-based approach.The European respiratory journal · 2024Article
- Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT.European radiology experimental · 2024Article
- Association between skin autofluorescence and coronary calcification in the general population.PloS one · 2024Article
- Reproducibility of a combined artificial intelligence and optimal-surface graph-cut method to automate bronchial parameter extraction.European radiology · 2023Article
- Emphysema Detection in the Course of Lung Cancer Screening: Optimizing a Rare Opportunity to Impact Population Health.Annals of the American Thoracic Society · 2023Article
Corrections and comments
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, based on pulmonary density and bronchial wall thickness, and of CAD, based on the coronary artery calcium score (CACS), at low radiation dose. To determine cut-off values for positive tests for elevated risk and presence of disease is one of the major tasks before considering implementation of CT screening in a general population. The ImaLife (Imaging in Lifelines) study, embedded in the Lifelines study, is designed to establish the reference values of the imaging biomarkers for the big three diseases in a well-defined general population aged 45 years and older. In total, 12,000 participants will undergo CACS and chest acquisitions with latest CT technology. The estimated percentage of individuals with lung nodules needing further workup is around 1-2%. Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. This information can be finally integrated into personalized precision health strategies in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.