Evidence map›Paper›PMID 31016417›Full record

ArticleJournal of cheminformatics2019

DNAmod: the DNA modification database.

Ankur Jai Sood, Coby Viner, Michael M Hoffman

Abstract read
In one paragraph

Article in Journal of cheminformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  20. SWAMNA: a comprehensive platform for analysis of nucleic acid modifications.Chemical communications (Cambridge, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ankur Jai SoodDepartment of Medical Biophysics, University of Toronto, Princess Margaret Cancer Research Tower 15-701, 101 College Street, Toronto, ON, M5G 1L7, Canada.
Coby VinerPrincess Margaret Cancer Centre, Princess Margaret Cancer Research Tower 11-311, 101 College Street, Toronto, ON, M5G 1L7, Canada.
Michael M HoffmanDepartment of Medical Biophysics, University of Toronto, Princess Margaret Cancer Research Tower 15-701, 101 College Street, Toronto, ON, M5G 1L7, Canada. michael.hoffman@utoronto.ca.

Funding

Canadian Cancer Society 703827Canadian Institutes of Health Research 201512MSH-360970Natural Sciences and Engineering Research Council of Canada CGSM-2015Natural Sciences and Engineering Research Council of Canada RGPIN-2015-03948Ontario Institute for Cancer Research CSC-FR-UHNOntario Ministry of Research, Innovation and Science ER-15-11-223Princess Margaret Cancer Foundation NoneSciences and Engineering Research Council of Canada CGSD3-504379-2017University of Toronto McLaughlin Center MC-2015-16
6 · The paper itself

Abstract

Covalent DNA modifications, such as 5-methylcytosine (5mC), are increasingly the focus of numerous research programs. In eukaryotes, both 5mC and 5-hydroxymethylcytosine (5hmC) are now recognized as stable epigenetic marks, with diverse functions. Bacteria, archaea, and viruses contain various other modified DNA nucleobases. Numerous databases describe RNA and histone modifications, but no database specifically catalogues DNA modifications, despite their broad importance in epigenetic regulation. To address this need, we have developed DNAmod: the DNA modification database. DNAmod is an open-source database ( https://dnamod.hoffmanlab.org ) that catalogues DNA modifications and provides a single source to learn about their properties. DNAmod provides a web interface to easily browse and search through these modifications. The database annotates the chemical properties and structures of all curated modified DNA bases, and a much larger list of candidate chemical entities. DNAmod includes manual annotations of available sequencing methods, descriptions of their occurrence in nature, and provides existing and suggested nomenclature. DNAmod enables researchers to rapidly review previous work, select mapping techniques, and track recent developments concerning modified bases of interest.

Indexed as

DNA modificationsEpigenomicsNucleobases

Identifiers

PMID31016417
PMCPMC6478773

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.