Evidence map›Paper›PMID 31016407›Full record

ArticleNanoscale research letters2019

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier.

L Kobylinska, I Ivasechko, N Skorokhyd, R Panchuk, A Riabtseva, N Mitina, A Zaichenko, R Lesyk, B Zimenkovsky, R Stoika and 1 more

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In one paragraph

Article in Nanoscale research letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

L KobylinskaDepartment of Biochemistry, Danylo Halytsky Lviv National Medical University, Pekarska St., 69a, Lviv, 79010, Ukraine. lesya8@gmail.com.ORCID http://orcid.org/0000-0002-8965-8436
I IvasechkoDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology, Drahomanov St., 14/16, Lviv, 79005, Ukraine.
N SkorokhydDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology, Drahomanov St., 14/16, Lviv, 79005, Ukraine.
R PanchukDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology, Drahomanov St., 14/16, Lviv, 79005, Ukraine.
A RiabtsevaDepartment of Organic Chemistry, Lviv Polytechnic National University, S. Bandera., 12, Lviv, 79013, Ukraine.
N MitinaDepartment of Organic Chemistry, Lviv Polytechnic National University, S. Bandera., 12, Lviv, 79013, Ukraine.
A ZaichenkoDepartment of Organic Chemistry, Lviv Polytechnic National University, S. Bandera., 12, Lviv, 79013, Ukraine.
R LesykDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St., 69a, Lviv, 79010, Ukraine.
B ZimenkovskyDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska St., 69a, Lviv, 79010, Ukraine.
R StoikaDepartment of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology, Drahomanov St., 14/16, Lviv, 79005, Ukraine.
S G VariInternational Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, CA, 90048-5502, USA. Sandor.Vari@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study whether water formulation of the complex of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier enhances their pro-apoptotic action towards rat glioma C6 cells.

methodsMechanisms of antineoplastic effects of 4-thiazolidinone derivatives were investigated in vitro with rat glioma C6 cells. Cell nativity, cell cycling pattern, and Annexin V expression were evaluated and DNA damage was estimated by DNA comet analysis. A novel water-based formulation of 4-thiazolidinone derivatives complexed with a polymeric nanocarrier was utilized for enhancing pro-apoptotic action towards C6 cells.

resultsThe studied 4-thiazolidinone derivatives use apoptosis mechanisms for killing rat glioma C6 cells, as confirmed by FACS analysis of these cells in pre-G1 stage, the appearance of Annexin V positive C6 cells, and an increased number of DNA comets of higher classes. Complexation of the studied compounds with a PEG-containing polymeric nanocarrier significantly increased pro-apoptotic effects in rat glioma C6 cells measured by all methods mentioned above.

conclusionComplexation of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier provided them with water solubility and enhanced pro-apoptotic effects in rat glioma C6 cells.

Indexed as

4-thiazolidinonesApoptosisPolyethylene glycolPolymeric nanocarrierRat glioma C6 cells

Identifiers

PMID31016407
PMCPMC6478785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.