Evidence map›Paper›PMID 31016342›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2021

Arterial waveform morphomics during hemorrhagic shock.

Philip J Wasicek, William A Teeter, Shiming Yang, Peter Hu, William B Gamble, Samuel M Galvagno, Melanie R Hoehn, Thomas M Scalea, Jonathan J Morrison

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A feasibility study of partial REBOA data in a high-volume trauma center.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Philip J WasicekR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
William A TeeterR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Shiming YangR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Peter HuR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
William B GambleR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Samuel M GalvagnoShock Trauma and Anesthesiology Research Center, University of Maryland, School of Medicine, Baltimore, MD, USA.
Melanie R HoehnR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Thomas M ScaleaR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA.
Jonathan J MorrisonR Adams Cowley Shock Trauma Center, 22 S. Greene Street, Baltimore, MD, 21201, USA. jonathan.morrison@som.umaryland.edu.ORCID http://orcid.org/0000-0001-7462-8456
University of Maryland, Baltimore · US

Funding

Medical Research and Materiel Command W81XWH-16-1-0116
6 · The paper itself

Abstract

purposeThe arterial pressure waveform is a composite of multiple interactions, and there may be more sensitive and specific features associated with hemorrhagic shock and intravascular volume depletion than systolic and/or diastolic blood pressure (BP) alone. The aim of this study was to characterize the arterial pressure waveform in differing grades of hemorrhage.

methodsTen anesthetized swine (70-90 kg) underwent a 40% controlled exponential hemorrhage. High-fidelity arterial waveform data were collected (500 Hz) and signal-processing techniques were used to extract key features. Regression modeling was used to assess the trend over time. Short-time Fourier transform (STFT) was utilized to assess waveform frequency and power spectrum density variance.

resultsAll animals tolerated instrumentation and hemorrhage. The primary antegrade wave (P1) was relatively preserved while the renal (P2) and iliac (P3) reflection waves became noticeably attenuated during progressive hemorrhage. Several features mirrored changes in systolic and diastolic BP and plateaued at approximately 20% hemorrhage, and were best fit with non-linear sigmoidal regression modeling. The P1:P3 ratio continued to change during progressive hemorrhage (R

conclusionsIn this swine model of volume-controlled hemorrhage, hypotension was a predominating early feature. While most waveform features mirrored those of BP, specific features such as the variance may be able to distinguish differing magnitudes of hemorrhage despite little change in conventional measures.

Indexed as

HypotensionShock, HemorrhagicAnimalsBlood PressureHemorrhageSwineArterial waveformExperimental hemorrhagic shockHemodynamic monitoringHemodynamic waveform analysisTraumaTraumatic shock

Identifiers

PMID31016342
OpenAlexW2942401055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.