Evidence map›Paper›PMID 31016326›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Which phosphodiesterase can decrease cardiac effects of 5-HT

Joachim Neumann, Benedikt Käufler, Ulrich Gergs

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Contractile effects of dulaglutide in the human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Felcisetrag stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  4. Clebopride stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  5. Bromopride stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  6. Inhibition of protein phosphatases attenuates ANaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  7. Studies on the mechanisms of action of MR33317.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  8. Mosapride stimulates human 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  9. Zacopride stimulates 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  10. Article
  11. Review
  12. OR-1896 increases force of contraction in the isolated human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  13. Ergometrine stimulates histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  14. Cardiovascular effects of bufotenin on human 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  15. Article
  16. Ergotamine Stimulates Human 5-HTInternational journal of molecular sciences · 2023
    Article
  17. Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease.International journal of molecular sciences · 2023
    Review
  18. Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of HNaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  19. Influence of Serotonin 5-HTBiomedicines · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, 06097, Halle, Germany.ORCID 0000-0001-5018-3851
Benedikt KäuflerInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, 06097, Halle, Germany.
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, 06097, Halle, Germany. ulrich.gergs@medizin.uni-halle.de.
Martin Luther University Halle-Wittenberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin (5-hydroxy-tryptamine, 5-HT) exerted concentration-dependent positive inotropic effects or positive chronotropic effects in transgenic (TG) mice which overexpress the human 5-HT

Indexed as

AnimalsCardiotonic AgentsElectrocardiographyHeartHeart RateHumansIsoenzymesMiceMice, TransgenicMyocardial ContractionPhosphodiesterase 3 InhibitorsPhosphodiesterase 4 InhibitorsPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesReceptors, Serotonin, 5-HT4SerotoninCardiotonic AgentsIsoenzymesPhosphodiesterase 3 InhibitorsPhosphodiesterase 4 InhibitorsPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesReceptors, Serotonin, 5-HT4SerotoninSerotonin 5-HT4 Receptor Antagonists5-HT4 receptorChronotropyInotropyPhosphodiesteraseSerotoninTransgenic mice

Identifiers

PMID31016326
OpenAlexW2941517263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.