ArticleBioMed research international2019
Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.Bioelectronic medicine · 2025Review
- Influence of Scaffold Structure and Biomimetic Properties on Adipose Stem Cell Homing in Personalized Reconstructive Medicine.Biomimetics (Basel, Switzerland) · 2025Review
- Biomimetic Design and Assessment via Microenvironmental Testing: From Food Packaging Biomaterials to Implantable Medical Devices.Biomimetics (Basel, Switzerland) · 2025Review
- 3D-Printed PLA Mechanical and Viscoelastic Behavior Dependence on the Nozzle Temperature and Printing Orientation.Polymers · 2025Article
- Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons.Frontiers in bioengineering and biotechnology · 2025Review
- Electrical Stimulation of Acute Fractures: A Narrative Review of Stimulation Protocols and Device Specifications.Frontiers in bioengineering and biotechnology · 2022Review
- Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts.Frontiers in physiology · 2022Article
- Electronic Bone Growth Stimulators for Augmentation of Osteogenesis inFrontiers in bioengineering and biotechnology · 2022Review
- Correlation of Statistical Distributions of the Dimension of Yeast Cells Attached to the Substrate and Its Surface Electrical Potential.Materials (Basel, Switzerland) · 2021Article
- Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook.Journal of functional biomaterials · 2021Review
- Anodic TiONanomaterials (Basel, Switzerland) · 2021Review
- Gradient 3D Printed PLA Scaffolds on Biomedical Titanium: Mechanical Evaluation and Biocompatibility.Polymers · 2021Article
- Biomedical applications of electrical stimulation.Cellular and molecular life sciences : CMLS · 2020Review
- Tissue-in-a-Tube: three-dimensionalMaterials today. Bio · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of an electric field within specific intensity limits on the activity of human cells has been previously investigated. However, there are a considerable number of factors that influence the in vitro development of cell populations. In biocompatibility studies, the nature of the substrate and its topography are decisive in osteoblasts bone cells development. Further on, electrical field stimulation may activate biochemical paths that contribute to a faster, more effective self-adjustment and proliferation of specific cell types on various nanosubstrates. Within the present research, an electrical stimulation device has been manufactured and optimum values of parameters that led to enhanced osteoblasts activity, with respect to the alkaline phosphatase and total protein levels, have been found. Homogeneous electric field distribution induced by a highly organized titanium dioxide nanotubes substrate had an optimum effect on cell response. Specific substrate topography in combination with appropriate electrical stimulation enhanced osteoblasts bone cells capacity to self-adjust the levels of their specific biomarkers. The findings are of importance in the future design and development of new advanced orthopaedic materials for hard tissue replacement.
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Registered trials
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