Evidence map›Paper›PMID 31016149›Full record

ArticleIndian journal of endocrinology and metabolism

Effect of Vitamin D Supplementation on Bone Turnover Markers in Children and Adolescents from North India.

Raman K Marwaha, M K Garg, A Mithal, Sushil Gupta, Manoj Shukla, Aditi Chadha

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  5. Interventions to improve vitamin and mineral inadequacies among children in India: a scoping review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
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  12. Article
  13. Effect of Vitamin D Levels on Bone Remodeling in Healthy Women.International journal of endocrinology and metabolism · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Raman K MarwahaInternational Life Science-India, Lajpat Nagar, New Delhi, India.
M K GargDepartment of Medicine and Endocrinology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
A MithalDepartment of Endocriology, Medanta Hospital, Gurgram, Haryana, India.
Sushil GuptaDepartment of Endocriology, Sanjay Gandhi Postgraduate Institute, Lucknow, Uttar Pradesh, India.
Manoj ShuklaDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Aditi ChadhaDepartment of Medicine, Dr. B R Sur Homeopathic Medical College, New Delhi, India.
Medanta The Medicity · INInternational Life Sciences Institute India · INSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesVitamin D is known to play an important role in bone mineral metabolism. Its deficiency may affect growth and status of bone markers in children. Hence, we undertook to study the status of bone markers in children with vitamin D deficiency (VDD) and impact of vitamin D3 supplementation on them. MATERIALS AND

methodsTotal 468 out of 615 children and adolescents with VDD, who were given either of the three doses (600, 1000, and 2000) of vitamin D supplementation, were included in the study. These 468 children with pre- and postsupplementation preserved samples with available anthropometry, serum biochemistry, 25-hydroxy-vitamin D, and parathormone were evaluated for bone formation (procollagen type 1 amino-terminal propeptide [P1NP]) and resorption (β-cross laps [CTx]) markers.

resultsThe mean age and body mass index of these children were 11.3 ± 2.3 years (boys: 11.5 ± 2.4; girls: 12.2 ± 1.2 years;

conclusionsVitamin D supplementation in VDD children resulted in decrease in both bone formation (P1NP) and resorption (CTx). The impact, however, was more marked on bone resorption than bone formation.

Indexed as

bone markersparathormoneprocollagen type-1 amino-terminal propeptideserum 25OHDvitamin D deficiencyβ-Cross laps

Identifiers

PMID31016149
PMCPMC6446672
OpenAlexW2921614096

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.