ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Cell-MICS: Detecting Immune Cells With Label-Free Two-Photon Autofluorescence and Deep Learning.Journal of biophotonics · 2026Article
- Challenges and Prospects of Using Novel Nonlinear Effects in Multimode Optical Fibers for Multiphoton Endomicroscopy.Diagnostics (Basel, Switzerland) · 2026Review
- Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography.Inflammatory bowel diseases · 2025Article
- Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy.Annals of biomedical engineering · 2024Article
- Resolution-enhanced multi-core fiber imaging learned on a digital twin for cancer diagnosis.Neurophotonics · 2024Article
- Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration.Biophysical reviews · 2024Review
- Label-free multimodal imaging with simultaneous two-photon and three-photon microscopy and kernel-based nonlinear scaling denoising.Biomedical optics express · 2024Article
- Imaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy.Frontiers in oncology · 2024Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Two-photon imaging reveals histopathological changes in the gastric tumor microenvironment induced by neoadjuvant treatment.Biomedical optics express · 2023Article
- SEMPAI: a Self-Enhancing Multi-Photon Artificial Intelligence for Prior-Informed Assessment of Muscle Function and Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Quantitative multiphoton imaging of cell metabolism, stromal fibers, and keratinization enables label-free discrimination of esophageal squamous cell carcinoma.Biomedical optics express · 2023Article
- Automatic and label-free detection of meningioma in dura mater using the combination of multiphoton microscopy and image analysis.Neurophotonics · 2023Article
- Toward next-generation endoscopes integrating biomimetic video systems, nonlinear optical microscopy, and deep learning.Biophysics reviews · 2023Review
- Article
- Two-Photon Endoscopy: State of the Art and Perspectives.Molecular imaging and biology · 2023Review
- Rapid and label-free detection of gastrointestinal stromal tumor via a combination of two-photon microscopy and imaging analysis.BMC cancer · 2023Article
- Super-resolution re-scan second harmonic generation microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging.Inflammatory bowel diseases · 2022Article
- Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiphoton microscopy of cellular autofluorescence and second harmonic generation from collagen facilitates imaging of living cells and tissues without the need for additional fluorescent labels. Here, a compact multiphoton endomicroscope for label-free in vivo imaging in small animals via side-viewing needle objectives is presented. Minimal invasive imaging at cellular resolution is performed in colonoscopy of mice without surgical measures and without fluorescent dyes as a contrast agent. The colon mucosa is imaged repeatedly in the same animal in a mouse model of acute intestinal inflammation to study the process of inflammation at the tissue level within a time period of ten days, demonstrating the capabilities of label-free endomicroscopy for longitudinal studies for the first time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.