Evidence map›Paper›PMID 31016031›Full record

ArticleNPJ Regenerative medicine2019

Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential.

Debora Kehl, Melanie Generali, Anna Mallone, Manfred Heller, Anne-Christine Uldry, Phil Cheng, Benjamin Gantenbein, Simon P Hoerstrup, Benedikt Weber

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06108388 (Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion in Type 2 Diabetes), which is not on this map. Cited by 118 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 2 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06108388 unknown statusnot on this mapstarted 2023, after this paper: background citation

Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion in Type 2 Diabetes

TypeobservationalSponsorCanadian Medical and Surgical Knowledge Translation Research GroupRan2023 to 2026Enrolled90ConditionsDiabetes Mellitus, Type 2
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Demographic Factors Affect the BMAC Proteome.Journal of proteome research · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Debora Kehl1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
Melanie Generali1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
Anna Mallone1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
Manfred Heller2Mass Spectrometry and Proteomics Core Facility, University of Bern, Bern, Switzerland.
Anne-Christine Uldry2Mass Spectrometry and Proteomics Core Facility, University of Bern, Bern, Switzerland.
Phil Cheng4Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Benjamin Gantenbein3Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Simon P Hoerstrup *1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
Benedikt Weber *1Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7217-4590
University of Zurich · CHUniversity of Bern · CHUniversity Hospital of Zurich · CHZurich University of Applied Sciences in Business Administration · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human mesenchymal stromal cell (hMSC) secretomes have shown to influence the microenvironment upon injury, promoting cytoprotection, angiogenesis, and tissue repair. The angiogenic potential is of particular interest for the treatment of ischemic diseases. Interestingly, hMSC secretomes isolated from different tissue sources have shown dissimilarities with respect to their angiogenic profile. This study compares angiogenesis of hMSC secretomes from adipose tissue (hADSCs), bone marrow (hBMSCs), and umbilical cord Wharton's jelly (hWJSCs). hMSC secretomes were obtained under xenofree conditions and analyzed by liquid chromatography tandem mass spectrometry (LC/MS-MS). Biological processes related to angiogenesis were found to be enriched in the proteomic profile of hMSC secretomes. hWJSC secretomes revealed a more complete angiogenic network with higher concentrations of angiogenesis related proteins, followed by hBMSC secretomes. hADSC secretomes lacked central angiogenic proteins and expressed most detected proteins to a significantly lower level. In vivo all secretomes induced vascularization of subcutaneously implanted Matrigel plugs in mice. Differences in secretome composition were functionally analyzed with monocyte and endothelial cell (EC) in vitro co-culture experiments using vi-SNE based multidimensional flow cytometry data analysis. Functional responses between hBMSC and hWJSC secretomes were comparable, with significantly higher migration of CD14

Identifiers

PMID31016031
PMCPMC6467904
OpenAlexW2940065032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.