Evidence map›Paper›PMID 31015940›Full record

ArticleChemical science2019

Controlling nanoemulsion surface chemistry with poly(2-oxazoline) amphiphiles.

Daniel A Estabrook, Amanda F Ennis, Rachael A Day, Ellen M Sletten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Functionalization of Emulsion Interfaces: Surface Chemistry Made Liquid.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  5. Review
  6. Article
  7. Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging.Angewandte Chemie (International ed. in English) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Reduction-Sensitive Fluorous Fluorogenic Coumarin.Synlett : accounts and rapid communications in synthetic organic chemistry · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel A EstabrookDepartment of Chemistry and Biochemistry , University of California , 607 Charles E. Young, Dr. E. , Los Angeles , CA 90095 , USA . Email: sletten@chem.ucla.edu.ORCID 0000-0001-7237-6291
Amanda F EnnisDepartment of Chemistry and Biochemistry , University of California , 607 Charles E. Young, Dr. E. , Los Angeles , CA 90095 , USA . Email: sletten@chem.ucla.edu.
Rachael A DayDepartment of Chemistry and Biochemistry , University of California , 607 Charles E. Young, Dr. E. , Los Angeles , CA 90095 , USA . Email: sletten@chem.ucla.edu.
Ellen M SlettenDepartment of Chemistry and Biochemistry , University of California , 607 Charles E. Young, Dr. E. , Los Angeles , CA 90095 , USA . Email: sletten@chem.ucla.edu.ORCID 0000-0002-0049-7278

Funding

Biotechnology Training in Biomedical Sciences and EngineeringT32GM067555 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GU, ZHEN · 2005 to 2019
$2.8M
NIGMS NIH HHS T32 GM067555
6 · The paper itself

Abstract

Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetic industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The controlled living polymerization of poly(2-oxazoline)s allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surface can be performed. Through post-emulsion modification of these new surfactants, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions in both macrophage and non-macrophage cell lines. We conclude that the cellular uptake and cytotoxicity of poly(2-oxazoline)-stabilized droplets can be systematically tuned

Identifiers

PMID31015940
PMCPMC6457192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.