ArticleChemical science2019
Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Asymmetric Mannich/Cyclization Reaction of 2-Benzothiazolimines and 2-Isothiocyano-1-indanones to Construct Chiral Spirocyclic Compounds.Molecules (Basel, Switzerland) · 2024Article
- Non-covalent organocatalyzed enantioselective cyclization reactions of α,β-unsaturated imines.Beilstein journal of organic chemistry · 2024Review
- Mild and efficient synthesis of benzothiazolopyrimidine derivativesRSC advances · 2023Article
- [3 + 2] cycloaddition of nonstabilized azomethine ylides and 2-benzothiazolamines to access imidazolidine derivatives.RSC advances · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A highly efficient catalytic enantioselective [4+2] cycloaddition was developed between 2-benzothiazolimines and enecarbamates. A wide range of benzothiazolopyrimidines bearing three contiguous stereogenic centers was obtained in high to excellent yields and with excellent diastereo- and enantioselectivities (d.r. > 98 : 2 and up to >99% ee). Furthermore, this chiral phosphoric acid-catalyzed strategy was scalable and enabled access to a new class of optically pure Lewis base isothiourea derivatives.
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Registered trials
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