Evidence map›Paper›PMID 31015911›Full record

ArticleMedChemComm2019

Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacterium

Katherine J Picott, Julie A Deichert, Ella M deKemp, Gabriele Schatte, Françoise Sauriol, Avena C Ross

Abstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Biosynthetic mechanism of the yellow pigments in the marine bacteriumApplied and environmental microbiology · 2024
    Article
  7. Anti-Microorganisms · 2023
    Review
  8. Article
  9. Marine Pyrrole Alkaloids.Marine drugs · 2021
    Review
  10. Total Synthesis and Antimalarial Activity of 2-(Journal of medicinal chemistry · 2021
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katherine J PicottDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.ORCID 0000-0003-3525-2366
Julie A DeichertDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.
Ella M deKempDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.
Gabriele SchatteDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.
Françoise SauriolDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.
Avena C RossDepartment of Chemistry , Queen's University , Kingston , ON , Canada . Email: avena.ross@queensu.ca.ORCID 0000-0002-9845-729X
Queen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tambjamines are natural products that consist of a conserved bipyrrole core functionalized with different imines giving rise to many derivatives. The core structure of tambjamines allows ion coordination through the nitrogen atoms, which is a key aspect in many of their observed antimicrobial, anticancer, and antimalarial bioactivities. Minor variances in the compound structure have a considerable impact on the potency of these activities, so identifying new analogues is valuable for maximizing tambjamine biological potential. In this work, we describe the isolation and structure elucidation of the first naturally occurring macrocyclized tambjamine, tambjamine MYP1, from the marine microbe

Identifiers

PMID31015911
PMCPMC6457199
OpenAlexW2918774548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.