Evidence map›Paper›PMID 31015889›Full record

ArticleOxidative medicine and cellular longevity2019

Aminated Graphene Oxide as a Potential New Therapy for Colorectal Cancer.

Natalia Krasteva, Milena Keremidarska-Markova, Kamelia Hristova-Panusheva, Tonya Andreeva, Giorgio Speranza, Dayong Wang, Milena Draganova-Filipova, George Miloshev, Milena Georgieva

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  7. Synthesis of Functionalized Carboxylated Graphene Oxide for the Remediation of Pb and Cr Contaminated Water.International journal of environmental research and public health · 2022
    Article
  8. Review
  9. Review
  10. Genotoxicity of Graphene-Based Materials.Nanomaterials (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Functionalized Graphene Platforms for Anticancer Drug Delivery.International journal of nanomedicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Natalia KrastevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.ORCID 0000-0001-7423-7412
Milena Keremidarska-MarkovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.ORCID 0000-0001-9385-6593
Kamelia Hristova-PanushevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.ORCID 0000-0001-8348-8336
Tonya AndreevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.ORCID 0000-0003-4062-6043
Giorgio SperanzaUniversity of Trento, Via alla Cascata, 56/C, 38123 Povo, Trento, Italy.ORCID 0000-0003-1478-0995
Dayong WangMedical School in Southeast University, 87 Dingjiaqiao Road, Gulou District, Nanjing 210009, China.
Milena Draganova-FilipovaDepartment of Medical Biology, Medical Faculty, Medical University - Plovdiv, Bulgaria.
George MiloshevInstitute of Molecular Biology "Acad. R. Tsanev", Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.
Milena GeorgievaInstitute of Molecular Biology "Acad. R. Tsanev", Bulgarian Academy of Sciences, "Acad. Georgi Bonchev", Str., Bl. 21, Sofia 1113, Bulgaria.ORCID 0000-0002-2371-7544
Bulgarian Academy of Sciences · BGMedical University Plovdiv · BGSoutheast University · CNUniversity of Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology-based drug delivery systems for cancer therapy are the topic of interest for many researchers and scientists. Graphene oxide (GO) and its derivates are among the most extensively studied delivery systems of this type. The increased surface area, elevated loading capacity, and aptitude for surface functionalization together with the ability to induce reactive oxygen species make GO a promising tool for the development of novel anticancer therapies. Moreover, GO nanoparticles not only function as effective drug carriers but also have the potential to exert their own inhibitory effects on tumour cells. Recent results show that the functionalization of GO with different functional groups, namely, with amine groups, leads to increased reactivity of the nanoparticles. The last steers different hypotheses for the mechanisms through which this functionalization of GO could potentially lead to improved anticancer capacity. In this research, we have evaluated the potential of amine-functionalized graphene oxide nanoparticles (GO-NH

Indexed as

AminesAnimalsCell CycleCell Line, TumorCell ProliferationCell ShapeCell SurvivalColorectal NeoplasmsDNA DamageGraphiteMiceNanoparticlesReactive Oxygen SpeciesAminesGraphiteReactive Oxygen Species

Identifiers

PMID31015889
PMCPMC6446092
OpenAlexW2923954273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.