ArticleCancer management and research2019
Inhibition of human glioblastoma cell invasion involves PION@E6 mediated autophagy process.
Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- Autophagy-Modulating Nanomedicine for Glioma: Delivery Barriers, Lysosomal Interactions, and a Flux-Resolved Translational Decision Framework.International journal of nanomedicine · 2026Review
- Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution.Frontiers in pharmacology · 2024Review
- Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway.Nano convergence · 2021Article
- Quantitative Ultrastructural Morphometry and Gene Expression of mTOR-Related Mitochondriogenesis within Glioblastoma Cells.International journal of molecular sciences · 2020Article
- Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway.OncoTargets and therapy · 2020Article
- LOX-1+ PMN-MDSC enhances immune suppression which promotes glioblastoma multiforme progression.Cancer management and research · 2019Article
- Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma.Cancer management and research · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioblastoma (GBM) is the most severe brain cancer due to its ability to invade surrounding brain tissue. Iron oxide nanoparticles (ION) could effectively induce a decrease of cell migration/invasion. Also IONs could generate ROS stress which induces autophagy elevation. Autophagy is associated with both anti-tumorigenesis and protumorigenesis.
objectiveTo explore the effect of PEGylated IONs (PION@E6) on the GBM cell invasion and its mechanism based on autophagy. MATERIALS AND
methodsPION@E6 were prepared and characterized according to our previous study. After incubation of U251 cells with PION@E6, cellular uptake of PION@E6 and cell viability were tested by Prussian blue staining and Cell Counting Kit-8, respectively. The migration and invasive capability was assessed by transwell cell migration and invasion assay. Expressions of autophagy biomarkers were detected by Western blotting. Intracellular ROS level was determined using 2'-7'-dichlorodihydrofluorescein diacetate.
resultsAverage hydrate particle size and zeta potential of PION@E6 were 37.86±12.90 nm and -23.8 mV, respectively, and uniformly distributed nanoparticles with an average diameter of 10 nm were observed by TEM. Chlorin e6 successfully incorporated onto PION@E6 was demonstrated by ultraviolet and visible absorption spectrophotometry, and PION@E6 owning excellent water solubility and stability were showed by Colloid stability test. PION@E6 were successfully taken up by U251 cells with Prussian blue staining, and they showed in vitro cytotoxicity to glioma cells after long incubation of 72 hours. Migration/invasion of cells was significantly inhibited by PION@E6, which could be counteracted by pretreatment with 3-MA. Additionally, the expression of beclin-1, IC3I, and IC3II proteins was higher, whereas that of p62 protein was lower. Moreover, a dose dependent intracellular ROS generation of PION@E6 was detected.
conclusionInvasiveness of human GBM cells involves the PION@E6-mediated autophagy process, which may be related to the intracellular ROS induced by PION@E6.
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