Evidence map›Paper›PMID 31015759›Full record

ReviewInternational journal of nanomedicine2019

The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism.

Iwona Lasocka, Elżbieta Jastrzębska, Lidia Szulc-Dąbrowska, Michał Skibniewski, Iwona Pasternak, Marie Hubalek Kalbacova, Ewa M Skibniewska

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iwona LasockaDepartment of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.
Elżbieta JastrzębskaDepartment of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland.
Lidia Szulc-DąbrowskaDepartment of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
Michał SkibniewskiDepartment of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland, michal_skibniewski@sggw.pl.
Iwona PasternakFaculty of Physics, Warsaw University of Technology, Warsaw, Poland.
Marie Hubalek KalbacovaInstitute of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, marie.kalbacova@lf1.cuni.cz.
Ewa M SkibniewskaDepartment of Animal Environment Biology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process. In addition, this study discusses the cytocompatibility of graphene, its uses as a platform for skin substitutes, the properties it possesses with respect to providing protection against microbial invasion as well as strategies aimed at minimizing the chance of the occurrence of sepsis. MSCs are capable of secreting several factors that exert a therapeutic impact on reparative processes and tissue regeneration. In light of experiments conducted to date, graphene combined with MSCs appears to have the potential to enhance both the wound healing process and infection control at the injury site.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsGraphiteHumansImmunomodulationMesenchymal Stem CellsSkinWound HealingGraphitegraphenehealingmesenchymal stem cellswound

Identifiers

PMID31015759
PMCPMC6448540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.