Evidence map›Paper›PMID 31015724›Full record

ArticleNature biomedical engineering2018

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

Zhen Ma, Nathaniel Huebsch, Sangmo Koo, Mohammad A Mandegar, Brian Siemons, Steven Boggess, Bruce R Conklin, Costas P Grigoropoulos, Kevin E Healy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
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  13. Generation and applications of cardiac spheroids.npj biomedical innovations · 2025
    Review
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Zhen MaDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Nathaniel HuebschDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Sangmo KooDepartment of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA.
Mohammad A MandegarGladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
Brian SiemonsDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Steven BoggessDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Bruce R ConklinGladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
Costas P GrigoropoulosDepartment of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA.
Kevin E HealyDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. kehealy@berkeley.edu.
University of California, Berkeley · USGladstone Institutes · USQB3 · USIncheon National University · KR

Funding

The Epigenetic Landscape of Heart DevelopmentU01HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BOYER, LAURIE A, BRUNEAU, BENOIT GAETAN · 2009 to 2014
$10.0M
Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart DiseasU01HL100406 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, CONKLIN, BRUCE R · 2009 to 2015
$9.4M
Training in Developmental Cardiovascular BiologyT32HL007544 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SRIVASTAVA, DEEPAK · 1985 to 2021
$4.5M
Modeling metabolic interactions of liver and fat with integrated microphysiological systemsUH3TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2014 to 2016
$2.9M
Disease Specific Cardiac Tissue ModelsR01HL108677 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONKLIN, BRUCE R, HEALY, KEVIN EDWARD · 2011 to 2014
$2.4M
Human heart-on-a-chip for screening cardiomyopathy and chemotherapeutic cardiotoxicityR01HL130417 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2017 to 2020
$2.3M
Protein quality control, cardiomyopathy, cardiotoxicity and human isogenic iPSCsR01HL135358 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2017 to 2020
$2.0M
Disease-Specific Integrated Microphysiological Human Tissue ModelsUH2TR000487 · NCATS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, LEE, LUKE P. · 2012 to 2013
$1.8M
Enabling Technologies for hES Cell Self-RenewalR01HL096525 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2009 to 2013
$1.8M
A Zeiss LSM 710 confocal microscope for the Biological Imaging Facility at the US10RR026866 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUZIN, STEVEN EARL · 2010 to 2010
$419k
iPSC Derived Cardiac Microchambers for Embryonic Drug ScreeningR21EB021003 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD · 2015 to 2016
$353k
American Heart Association-American Stroke Association 16POST27750031NCATS NIH HHS UH2 TR000487NCATS NIH HHS UH3 TR000487NCRR NIH HHS S10 RR026866NHLBI NIH HHS R01 HL096525NHLBI NIH HHS R01 HL108677NHLBI NIH HHS R01 HL130417NHLBI NIH HHS R01 HL135358NHLBI NIH HHS T32 HL007544NHLBI NIH HHS U01 HL098179NHLBI NIH HHS U01 HL100406NIBIB NIH HHS R21 EB021003
6 · The paper itself

Abstract

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue model consisting of filamentous three-dimensional matrices populated with cardiomyocytes derived from healthy wild-type (WT) hiPSCs (WT hiPSC-CMs) or isogenic hiPSCs deficient in the sarcomere protein cardiac myosin-binding protein C (MYBPC3

Indexed as

Myocardial ContractionStress, MechanicalTissue EngineeringCalciumCardiomyopathy, DilatedCarrier ProteinsCells, CulturedE1A-Associated p300 ProteinGATA4 Transcription FactorGene Knockout TechniquesHumansInduced Pluripotent Stem CellsMyocardiumMyocytes, CardiacMyosin Binding Protein CSarcomeresCalciumCarrier ProteinsE1A-Associated p300 ProteinEP300 protein, humanGATA4 protein, humanGATA4 Transcription FactorMyosin Binding Protein C

Identifiers

PMID31015724
PMCPMC6482859
OpenAlexW2889316118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.