ArticleScientific reports2019
Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of supplementing concentrates with different energy levels on growth performance, blood indicators, and fecal microbiota of Mongolian horses in late gestation.BMC veterinary research · 2026Article
- The Effects of L-Citrulline on the Apparent Digestion and Metabolism of Nutrients, Blood Hormone Levels, Amino Acid Metabolism and the Diversity of Faecal Microbiota in Mares in the Later Stage of Pregnancy.Life (Basel, Switzerland) · 2026Article
- Strategic approaches to improve equine breeding and stud farm outcomes.Veterinary world · 2025Review
- Supplementary L-arginine can enhance reproductive parameters and outcomes in large mammals.Frontiers in veterinary science · 2025Review
- Effects of maternal dietary supplementation with antioxidants on clinical status of mares and their foal.BMC veterinary research · 2024Article
- Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Evaluation of dietary arginine supplementation to increase placental nutrient transporters in aged mares.Translational animal science · 2023Article
- The effects of obesity and insulin dysregulation on mare reproduction, pregnancy, and foal health: a review.Frontiers in veterinary science · 2023Review
- Sources of variation of DNA methylation in rainbow trout: combined effects of temperature and genetic background.Epigenetics · 2021Article
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foals born to primiparous mares are lighter and less mature than those born to multiparous dams. Factors driving this difference are not totally understood. Using 7 multiparous and 6 primiparous standardbred mares, we demonstrated that, in late gestation, primiparous mares were less insulin resistant compared to multiparous mares, and that their foals had reduced plasma amino-acid concentrations at birth compared to foals born to multiparous mares. Vascular development, as observed through structure and gene expression, and global DNA methylation were also reduced in primiparous placentas. Another group of 8 primiparous mares was orally supplemented with L-arginine (100 g/day, 210d to term). L-arginine improved pregnancy-induced insulin resistance and increased maternal L-arginine and L-ornithine plasma concentrations but foal plasma amino acid concentrations were not affected at birth. At birth, foal weight and placental biometry, structure, ultra-structure and DNA methylation were not modified. Placental expression of genes involved in glucose and fatty acid transfers was increased. In conclusion, maternal insulin resistance in response to pregnancy and placental function are reduced in primiparous pregnancies. Late-gestation L-arginine supplementation may help primiparous mares to metabolically adapt to pregnancy and improve placental function. More work is needed to confirm these effects and ascertain optimal treatment conditions.
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