Evidence map›Paper›PMID 31015511›Full record

ArticleScientific reports2019

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

Elinor Hortle, Lora Starrs, Fiona C Brown, Stephen M Jane, David J Curtis, Brendan J McMorran, Simon J Foote, Gaetan Burgio

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elinor HortleDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia.
Lora StarrsDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia.
Fiona C BrownAustralian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia.
Stephen M JaneAustralian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia.
David J CurtisAustralian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Australia.
Brendan J McMorranDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia.
Simon J FooteDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia.
Gaetan BurgioDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Australia. Gaetan.burgio@anu.edu.au.ORCID http://orcid.org/0000-0002-7434-926X
Australian National University · AUThe Alfred Hospital · AUAustralian Centre for HIV and Hepatitis Virology Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1

Indexed as

Ion Channel GatingAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDisease ResistanceFemaleInflammation MediatorsMalaria, CerebralMaleMice, Inbred BALB CMice, Inbred C57BLMutationPlasmodium bergheiSolute Carrier Family 12, Member 4CytokinesInflammation MediatorsSolute Carrier Family 12, Member 4

Identifiers

PMID31015511
PMCPMC6478876
OpenAlexW2951215359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.