Evidence map›Paper›PMID 31015489›Full record

ArticleNature communications2019

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome.

Ramadan A Ali, Alex A Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P Vreede, Shanea K Estes, Olivia R Palmer, Paula L Bockenstedt, David J Pinsky, Joan M Greve and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 197 citations in OpenAlex.

  1. Article
  2. Article
  3. Antiphospholipid syndrome and pregnancy-a hematologic perspective.Research and practice in thrombosis and haemostasis · 2026
    Article
  4. Review
  5. Review
  6. Relationship of Circulatory Markers of NETosis with COVID-19 Severity: A Prospective Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Getting to know adenosine deaminase 2 deficiency inside and out.The Journal of allergy and clinical immunology · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Neutrophil extracellular traps in homeostasis and disease.Signal transduction and targeted therapy · 2024
    Review
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ramadan A AliDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Alex A GandhiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
He MengDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Srilakshmi YalavarthiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Andrew P VreedeDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Shanea K EstesDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Olivia R PalmerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Paula L BockenstedtDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
David J PinskyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Joan M GreveDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Jose A DiazDepartment of Vascular Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Yogendra KanthiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Jason S KnightDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. jsknight@umich.edu.
University of Michigan–Ann Arbor · US

Funding

TRAINING OF ARTHRITIS RESEARCH SCIENTISTST32AR007080 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 1986 to 2026
$6.3M
Purinergic modulation of the autoimmune vascular phenotypeR01HL134846 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 2018 to 2026
$4.8M
Thrombo-Inflammatory Role of CD39 In Vascular StasisR01HL127151 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PINSKY, DAVID J. · 2015 to 2018
$2.0M
CD39 in Vein Graft ArterializationK08HL131993 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KANTHI, YOGENDRA · 2016 to 2020
$837k
Innate Immunity in the Pathogenesis of Lupus and Antiphospholipid VasculopathyK08AR066569 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KNIGHT, JASON · 2014 to 2018
$692k
Mentored training in comprehensive mouse phenotyping (K26)K26OD016502 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MICHELE, DANIEL E · 2013 to 2017
$391k
NHLBI NIH HHS K08 HL131993NHLBI NIH HHS L30 HL129373NHLBI NIH HHS R01 HL127151NHLBI NIH HHS R01 HL134846NIAMS NIH HHS K08 AR066569NIAMS NIH HHS T32 AR007080NIH HHS K26 OD016502
6 · The paper itself

Abstract

Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS). Surface adenosine receptors trigger cyclic AMP (cAMP) formation in neutrophils, and this mechanism has been proposed to regulate NETosis in some contexts. Here we report that selective agonism of the adenosine A

Indexed as

AdenosineAdenosine A2 Receptor AgonistsAnimalsAntibodies, AntiphospholipidAntiphospholipid SyndromeCyclic AMPDipyridamoleDisease Models, AnimalExtracellular TrapsFibrinolytic AgentsGene Expression RegulationHumansImmunoglobulin GMaleMiceMice, Inbred C57BL2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineAdenosineAdenosine A2 Receptor AgonistsAntibodies, AntiphospholipidCyclic AMPDipyridamoleFibrinolytic AgentsImmunoglobulin GPhenethylaminesReceptor, Adenosine A2A

Identifiers

PMID31015489
PMCPMC6478874
OpenAlexW2941655528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.