Evidence map›Paper›PMID 31015461›Full record

SynthesisNature communications2019

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Leanne K Küpers, Claire Monnereau, Gemma C Sharp, Paul Yousefi, Lucas A Salas, Akram Ghantous, Christian M Page, Sarah E Reese, Allen J Wilcox, Darina Czamara and 117 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

127 authors.

Leanne K KüpersMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Claire MonnereauThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Gemma C SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-2906-4035
Paul YousefiMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Lucas A SalasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0002-2279-4097
Akram GhantousEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Sarah E ReeseEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.
Allen J WilcoxEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.
Darina CzamaraDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Anne P StarlingDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Alexei NovoloacaEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Samantha LentDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ritu RoyHDF Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Carrie V BretonDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Catherine AllardCentre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.ORCID http://orcid.org/0000-0002-8829-4984
Allan C JustDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9605-6337
John W HollowayClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-9998-0464
Todd M EversonDepartment of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
Cheng-Jian XuUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1586-4672
Rae-Chi HuangTelethon Kids Institute, University of Western Australia, Perth, Australia.
Diana A van der PlaatUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Simon Kebede MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Faisal I RezwanHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID http://orcid.org/0000-0001-9921-222X
Jari LahtiHelsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Jenny van DongenDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2063-8741
Sabine A S LangieVITO - Health, Mol, Belgium.
Tom G RichardsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7918-2040
Maria C MagnusMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Ellen A NohrResearch Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Zongli XuDepartment of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Liesbeth DuijtsDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Shanshan ZhaoBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA.
Weiming ZhangDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michelle PlusquinCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Olivia SolomonSchool of Oral and Dental Sciences, University of Bristol, Bristol, UK.
Joosje H HeimovaaraUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Dereje D JimaCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Lu GaoDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Mariona BustamanteISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Patrice PerronCentre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences, School of Medicine, University of California Davis MIND Institute, Sacramento, CA, USA.
Hongmei ZhangDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Carmen J MarsitDepartment of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4566-150X
Lawrence J BeilinMedical School, University of Western Australia, Perth, Australia.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anne K ÖrtqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Susan EwartCollege of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Pia M VillaObstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sophie E MooreMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
Gonneke WillemsenDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Arnout R L StandaertVITO - Health, Mol, Belgium.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Thorkild I A SørensenMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4821-430X
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ivana V YangDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katerina KechrisDepartment of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Tim S NawrotCentre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Matt J SilverMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-3852-9677
Yun Yun GongSchool of Food Sciences and Nutrition, University of Leeds, Leeds, UK.
Lorenzo RichiardiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Manolis KogevinasISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Augusto A LitonjuaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brenda EskenaziChildren's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Karen HuenChildren's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Hamdi MbarekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1108-0371
Rachel L MaguireDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Terence DwyerThe George Institute for Global Health, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Martine VrijheidISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Luigi BouchardDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
Andrea A BaccarelliLaboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0001-7849-9428
Wilfried KarmausDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Denise AndersonTelethon Kids Institute, University of Western Australia, Perth, Australia.ORCID http://orcid.org/0000-0003-0643-4136
Maaike de VriesUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Sylvain SebertCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Juha KereFolkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1974-0271
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Syed Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Esa HämäläinenHUSLAB and the Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.
Michael N RoutledgeLICAMM, School of Medicine, Univeristy of Leeds, Leeds, UK.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Andrew P FeinbergCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MA, USA.ORCID http://orcid.org/0000-0002-8364-1991
Craig J NewschafferAJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Eva GovartsVITO - Health, Mol, Belgium.
Matthieu MoisseKU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, Belgium.ORCID http://orcid.org/0000-0001-8880-9311
M Daniele FallinDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Andrew M PrenticeMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
Eero KajantieNational Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Emily OkenDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, and Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
H Marike BoezenUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Phillip E MeltonCentre for Genetic Origins of Health and Disease, School of Biomedical Sciences, University of Western Australia, Perth, Australia.ORCID http://orcid.org/0000-0003-4026-2964
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
Letizia TrevisiDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Marie-France HivertDepartment of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada.
Jordi SunyerISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Monica C Munthe-KaasNorwegian Institute of Public Health, Oslo, Norway.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Eva CorpeleijnUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Joseph WiemelsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Nina HollandChildren's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer, Lyon, France.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Rolv T LieCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Wenche NystadDepartment for Non-Communicable Diseases, Norwegian Institute for Public Health, Oslo, Norway.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.ORCID http://orcid.org/0000-0003-4911-5290
Debbie A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. d.a.Lawlor@bristol.ac.uk.ORCID http://orcid.org/0000-0002-6793-2262
Caroline L ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. caroline.relton@bristol.ac.uk.
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands. h.snieder@umcg.nl.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.ORCID http://orcid.org/0000-0002-9801-5774

Funding

A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Environmental Exposure and DNA DamageZIAES049032 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$13.4M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Environment, Imprinting, and NeurodevelopmentR01ES022223 · NIEHS · EMORY UNIVERSITY · PI CHEN, JIA, MARSIT, CARMEN JOSEPH · 2013 to 2017
$4.3M
Racial inequalities in health throughout adulthood: The cumulative impact of neighborhood chemical and non-chemical stressors on epigenomic pathwaysR01MD013299 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2018 to 2022
$3.7M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in UteroR01ES021369 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2013 to 2017
$3.1M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
Medical Research Council MC_EX_MR/M01424X/1Medical Research Council MC_U123292700Medical Research Council MC_U123292701Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00026/3Medical Research Council MC_UU_12013/2Medical Research Council MR/P012019/1Medical Research Council MR/S003886/1Medical Research Council MR/S019669/1World Health Organization 001
6 · The paper itself

Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P

Indexed as

Epigenesis, GeneticGenome, HumanAdolescentAdultBirth WeightBody Mass IndexChildCpG IslandsDNADNA MethylationFemaleFetal DevelopmentFetusFolic AcidGenome-Wide Association StudyHumansDNAFolic Acid

Identifiers

PMID31015461
PMCPMC6478731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.