ArticleNature communications2019
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 6 of them syntheses that pooled it.
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195citing papers in PubMed, 6 pooled it
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Who cites it
195 citing papers in PubMed, 6 syntheses or guidelines pooled it, 291 citations in OpenAlex.
- A bibliometric study of global trends in diabetic nephropathy and intestinal flora research.Frontiers in microbiology · 2025Pooled it
- Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study.Renal failure · 2024Pooled it
- Association between Gut Microbiota Compositions with MicrovascularComplications in Individuals with Diabetes: A Systematic Review.Current diabetes reviews · 2024Pooled it
- Investigating the causal association between gut microbiota and type 2 diabetes: a meta-analysis and Mendelian randomization.Frontiers in public health · 2024Pooled it
- Specific alterations of gut microbiota in diabetic microvascular complications: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- The Specific Alteration of Gut Microbiota in Diabetic Kidney Diseases-A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial.Science advances · 2025Trial
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study.Pharmaceutical biology · 2024Trial
- A Polyphenol-Rich Diet Increases the Gut Microbiota Metabolite Indole 3-Propionic Acid in Older Adults with Preserved Kidney Function.Molecular nutrition & food research · 2022Trial
- Diagnostic model for predicting hyperuricemia based on alterations of the gut microbiome in individuals with different serum uric acid levels.Frontiers in endocrinology · 2022Trial
- Colonic dialysis can influence gut flora to protect renal function in patients with pre-dialysis chronic kidney disease.Scientific reports · 2021Trial
- Intervention Value of Path-Type Health Education on Cognition and Renal Function of Patients with Diabetic Nephropathy.Computational and mathematical methods in medicine · 2021Trial
- Metabolic reprogramming in diabetic panvascular disease: Molecular mechanism and therapeutic strategies.iScience · 2026Review
- Au(I) Complex With an Abnormal Carbene Ligand Shows Anti-Kasha Dual Photoluminescence Emission.Angewandte Chemie (International ed. in English) · 2026Article
- Digestion-resistant proteins support the healthy metabolite profiles associated with plant-based diets.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Host metabolism can produce many indoles and phenols independently of the microbiome.Nature metabolism · 2026Article
- An oral tyrosine challenge test for functional phenotyping of microbiota-derived phenyl sulfate production.npj metabolic health and disease · 2026Article
- Extraintestinal Manifestations of Inflammatory Bowel Disease: A Focus on Kidney Complications.International journal of molecular sciences · 2026Review
- Autism and the gut metabolome: Evidence for altered short-chain fatty acid profiles from a systematic review and meta-analysis.Brain, behavior, & immunity - health · 2026Review
135 more citing papers are in PubMed but not listed here.
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Authors and funding
56 authors at 9 institutions in 2 countries.
Koichi KikuchiDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Daisuke SaigusaDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Yoshitomi KanemitsuLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Yotaro MatsumotoLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Paxton ThanaiWaters Corporation, Tokyo, 140-0001, Japan.
Naoto SuzukiLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Koki MiseDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.ORCID http://orcid.org/0000-0003-0296-7429
Hiroaki YamaguchiDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, 980-8574, Japan.
Tomohiro NakamuraDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Kei AsajiLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Chikahisa MukawaLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Hiroki TsukamotoLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.ORCID http://orcid.org/0000-0002-4585-1656
Toshihiro SatoDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, 980-8574, Japan.ORCID http://orcid.org/0000-0002-8807-2417
Yoshitsugu OikawaDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Tomoyuki IwasakiDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yuji OeDivision of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Tomoya TsukimiInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0052, Japan.
Noriko N FukudaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0052, Japan.
Hsin-Jung HoDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Fumika Nanto-HaraDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Jiro OguraDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, 980-8574, Japan.
Ritsumi SaitoDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Shizuko NagaoEducation and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
Yusuke OhsakiDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Satoshi ShimadaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.ORCID http://orcid.org/0000-0001-5293-572X
Takehiro SuzukiDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Takafumi ToyoharaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Eikan MishimaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Hisato ShimaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.ORCID http://orcid.org/0000-0003-3918-4735
Yasutoshi AkiyamaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yukako AkiyamaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Mariko IchijoDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Tetsuro MatsuhashiDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Akihiro MatsuoDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yoshiaki OgataDepartment of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Ching-Chin YangDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Chitose SuzukiDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Matthew C BreeggemannKidney Diseases Branch, NIDDK, NIH, Bethesda, MD, 20892-1268, USA.ORCID http://orcid.org/0000-0003-3707-8103
Jurgen HeymannKidney Diseases Branch, NIDDK, NIH, Bethesda, MD, 20892-1268, USA.
Miho ShimizuDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, 920-8641, Japan.
Susumu OgawaDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Nobuyuki TakahashiDivision of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Takashi SuzukiDepartment of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yuji OwadaDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Shigeo KureDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Nariyasu ManoDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, 980-8574, Japan.
Tomoyoshi SogaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0052, Japan.
Takashi WadaDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, 920-8641, Japan.
Jeffrey B KoppKidney Diseases Branch, NIDDK, NIH, Bethesda, MD, 20892-1268, USA.
Shinji FukudaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0052, Japan.
Atsushi HozawaDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Masayuki YamamotoDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Sadayoshi ItoDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Jun WadaDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Yoshihisa TomiokaLaboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Takaaki AbeDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. takaabe@med.tohoku.ac.jp.ORCID http://orcid.org/0000-0003-3170-4660
Tohoku University · JPSendai University · JPTohoku University Hospital · JPKeio University · JPNational Institutes of Health · USKanazawa University · JPOkayama University · JPFujita Health University · JPUniversity of Tsukuba · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. In a diabetic patient cohort, phenyl sulfate levels significantly correlate with basal and predicted 2-year progression of albuminuria in patients with microalbuminuria. Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. Together, our results suggest that phenyl sulfate contributes to albuminuria and could be used as a disease marker and future therapeutic target in diabetic kidney disease.
Indexed as
AdultAgedAged, 80 and overAlbuminuriaAnimalsAnimals, Genetically ModifiedCohort StudiesDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesDogsEnzyme InhibitorsFemaleGastrointestinal MicrobiomeHumansEnzyme InhibitorsOrganic Anion TransportersphenylsulfateSLCO4C1 protein, humanStreptozocinSulfuric Acid EstersTyrosine Phenol-Lyase
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