Evidence map›Paper›PMID 31015414›Full record

ArticleNature communications2019

Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells.

Snezana Raus Balind, Ádám Magó, Mahboobeh Ahmadi, Noémi Kis, Zsófia Varga-Németh, Andrea Lőrincz, Judit K Makara

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Distinct types of dendritic CaScience advances · 2026
    Article
  2. Article
  3. Increased CA3 burst activity inbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  10. Article
  11. Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Cholinergic regulation of dendritic CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Dorsoventral Heterogeneity of Synaptic Connectivity in Hippocampal CA3 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  16. Intrinsic and Synaptic Contributions to Repetitive Spiking in Dentate Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Article
  18. Article
  19. Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Snezana Raus BalindLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Ádám MagóLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Mahboobeh AhmadiLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Noémi KisLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Zsófia Varga-NémethLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Andrea LőrinczLaboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary.
Judit K MakaraLaboratory of Neuronal Signaling, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Str., 1083, Budapest, Hungary. makara.judit@koki.mta.hu.

Funding

Wellcome TrustWellcome Trust 090915/Z/09/Z
6 · The paper itself

Abstract

Complex spike bursts (CSBs) represent a characteristic firing pattern of hippocampal pyramidal cells (PCs). In CA1PCs, CSBs are driven by regenerative dendritic plateau potentials, produced by correlated entorhinal cortical and CA3 inputs that simultaneously depolarize distal and proximal dendritic domains. However, in CA3PCs neither the generation mechanisms nor the computational role of CSBs are well elucidated. We show that CSBs are induced by dendritic Ca

Indexed as

Action PotentialsAnimalsCA3 Region, HippocampalCalciumCations, DivalentDendritesMaleMemoryModels, AnimalPatch-Clamp TechniquesPyramidal CellsRats, WistarCalciumCations, Divalent

Identifiers

PMID31015414
PMCPMC6478939

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.