ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Reward Prediction Error Modulates Saccade Vigor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 54 citations in OpenAlex.
- Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation.Science advances · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Rapid Dopaminergic Signatures in Movement: Reach Vigor Reflects Reward Prediction Error and Learned Expectation.bioRxiv : the preprint server for biology · 2025Article
- Reward influences movement vigor through multiple motor cortical mechanisms.bioRxiv : the preprint server for biology · 2025Article
- Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder.Translational psychiatry · 2025Article
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- Neural mechanisms for executive control of speed-accuracy trade-off.Cell reports · 2023Article
- Common Mechanisms of Learning in Motor and Cognitive Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- The temporal dynamics of emotion comparison depends on low-level attentional factors.Scientific reports · 2023Article
- Modulation of Motor Vigor by Expectation of Reward Probability Trial-by-Trial Is Preserved in Healthy Ageing and Parkinson's Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Explicit learning based on reward prediction error facilitates agile motor adaptations.PloS one · 2023Article
- The dopamine circuit as a reward-taxis navigation system.PLoS computational biology · 2022Article
- Motor response vigour and visual fixation patterns reflect subjective valuation during intertemporal choice.PLoS computational biology · 2022Article
- The Cost of Imagined Actions in a Reward-Valuation Task.Brain sciences · 2022Article
- Using Artificial Intelligence for Assistance Systems to Bring Motor Learning Principles into Real World Motor Tasks.Sensors (Basel, Switzerland) · 2022Review
- Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits.PLoS computational biology · 2022Article
- How the value of the environment controls persistence in visual search.PLoS computational biology · 2021Article
- The cost of correcting for error during sensorimotor adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cerebellar complex spikes multiplex complementary behavioral information.PLoS biology · 2021Article
- Vision as oculomotor reward: cognitive contributions to the dynamic control of saccadic eye movements.Cognitive neurodynamics · 2021Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
Movement vigor, defined as the reciprocal of the latency from availability of reward to its acquisition, changes with reward magnitude: movements exhibit shorter reaction time and increased velocity when they are directed toward more rewarding stimuli. This invigoration may be due to release of dopamine before movement onset, which has been shown to be modulated by events that signal reward prediction error (RPE). Here, we generated an RPE event in the milliseconds before movement onset and tested whether there was a relationship between RPE and vigor. Human subjects (both sexes) made saccades toward an image. During execution of the primary saccade, we probabilistically changed the position and content of that image, encouraging a secondary saccade. On some trials, the content of the secondary image was more valuable than the first image, resulting in a positive RPE (+RPE) event that preceded the secondary saccade. On other trials, this content was less valuable (-RPE event). We found that reaction time of the secondary saccade was affected in an orderly fashion by the magnitude and direction of the preceding RPE event: the most vigorous saccades followed the largest +RPE, whereas the least vigorous saccades followed the largest -RPE. Presence of the secondary saccade indicated that the primary saccade had experienced a movement error, inducing trial-to-trial adaptation. However, this learning from movement error was not modulated by the RPE event. The data suggest that RPE events, which are thought to transiently alter the release of dopamine, modulate the vigor of the ensuing movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.