Evidence map›Paper›PMID 31015335›Full record

ArticleThe EMBO journal2019

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

Francesca Farina, Nitya Ramkumar, Louise Brown, Dureen Samandar Eweis, Jannis Anstatt, Thomas Waring, Jessica Bithell, Giorgio Scita, Manuel Thery, Laurent Blanchoin and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
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  4. Torques within and outside the human spindle balance twist at anaphase.bioRxiv : the preprint server for biology · 2023
    Article
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  15. Review
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  17. Article
  18. Article
  19. Mitosis, Focus on Calcium.Frontiers in physiology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Francesca FarinaMRC-LMCB, UCL, London, UK.
Nitya RamkumarMRC-LMCB, UCL, London, UK n.ramkumar@ucl.ac.uk b.baum@ucl.ac.uk.ORCID 0000-0002-4086-4562
Louise BrownInstitute of Translational Medicine, Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.
Dureen Samandar EweisMRC-LMCB, UCL, London, UK.
Jannis AnstattMRC-LMCB, UCL, London, UK.
Thomas WaringInstitute of Translational Medicine, Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.
Jessica BithellInstitute of Translational Medicine, Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.
Giorgio ScitaIFOM, the FIRC Institute of Molecular Oncology, University of Milan, Milan, Italy.ORCID 0000-0001-7984-1889
Manuel TheryHospital Saint-Louis, Paris, France.ORCID 0000-0002-9968-1779
Laurent BlanchoinUniversity of Grenoble, Grenoble, France.ORCID 0000-0001-8146-9254
Tobias ZechInstitute of Translational Medicine, Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.
Buzz BaumMRC-LMCB, UCL, London, UK n.ramkumar@ucl.ac.uk b.baum@ucl.ac.uk.
Public Library of Science · USUniversity of Liverpool · GBSaint Louis University Hospital · USUniversité Grenoble Alpes · FRUniversity of Milan · IT

Funding

Biotechnology and Biological Sciences Research Council BB/R009732/1Cancer Research UK 17343Cancer Research UK 23335Cancer Research UK 9786Medical Research Council MR/S008632/1
6 · The paper itself

Abstract

Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule dynamics and organisation. While most evidence suggests that the two cytoskeletal systems are remodelled in parallel during mitosis, recent work in interphase cells has implicated the centrosome in both microtubule and actin nucleation, suggesting the potential for regulatory crosstalk between the two systems. Here, by using both

Indexed as

Actin CytoskeletonActinsCells, CulturedCentrosomeCytoskeletonHeLa CellsHumansInterphaseJurkat CellsMicrotubulesMitosisProtein MultimerizationActinsArp2/3 complexcentrosomal actinmitosisWASH complex

Identifiers

PMID31015335
PMCPMC6545563
OpenAlexW2941086575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.