ArticleProceedings of the National Academy of Sciences of the United States of America2019
Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer's disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Virtual reality-based cognitive training in mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Virtual Reality and Serious Videogame-Based Instruments for Assessing Spatial Navigation in Alzheimer's Disease: A Systematic Review of Psychometric Properties.Neuropsychology review · 2025Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Article
- Article
- NavegApp, a serious game for assessing spatial cognition: Diagnostic accuracy in preclinical and prodromal Alzheimer's disease.PLOS digital health · 2026Article
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks.Behavior research methods · 2026Article
- Analysis of Spatiotemporal Features in a Virtual Navigation Game Across Different Age Groups: Quantitative Research.JMIR serious games · 2026Article
- AI-enabled digital phenotyping for Alzheimer's disease: a review of multimodal sensor integration and symptom trajectories.Alzheimer's research & therapy · 2026Review
- Spatial navigation as a digital marker for clinically differentiating cognitive impairment severity.Communications medicine · 2026Article
- Egocentric Spatial Memory Deficit in Amnestic Mild Cognitive Impairment Revealed Through Virtual Reality: Cross-Sectional Study.JMIR aging · 2026Article
- A Pocket Laboratory for Functional Neuroimaging Research Using Mobile Visual Oddball, Multimodal Electroencephalography, and Functional Near-Infrared Spectroscopy Imaging: Instrument Validation Study.JMIR neurotechnology · 2026Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Using Virtual Reality to Assess Spatial Navigation Ability in Individuals With Mild Cognitive Impairment and Older Adults: Cross-Sectional Study.JMIR aging · 2025Article
- Investigating the associations between tau and mental orientation among cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025Article
- Separable cognitive and motor decline tracked across adult life-span for goal-directed navigation.iScience · 2025Article
- Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype.Journal of neurology · 2025Article
- Impact of APOE4-related dementia risk in underrepresented groups from the All of Us research program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study.JMIR serious games · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer's disease (AD). However, the impact of interindividual navigation ability and demographic risk factors (e.g., APOE, age, and sex) on spatial navigation make it difficult to identify persons "at high risk" of AD in the preclinical stages. In the current study, we use spatial navigation big data (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.