Evidence map›Paper›PMID 31015254›Full record

ArticleMolecular cancer research : MCR2019

The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.

Lauren J Tracey, Travis Brooke-Bisschop, Pascal W T C Jansen, Eric I Campos, Michiel Vermeulen, Monica J Justice

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Multifaceted Role of PRDM Proteins in Human Cancer.International journal of molecular sciences · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lauren J TraceyDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Travis Brooke-BisschopGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-4450-5572
Pascal W T C JansenFaculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, the Netherlands.
Eric I CamposDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Michiel VermeulenFaculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, the Netherlands.
Monica J JusticeDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. monica.justice@sickkids.ca.ORCID 0000-0003-3562-2099
University of Toronto · CARadboud University Nijmegen · NLHospital for Sick Children · CA

Funding

The pluripotency regulator Prdm14 initiates cancer by epigenetic mechanismsR01CA163849 · NCI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI JUSTICE, MONICA J., MILOSAVLJEVIC, ALEKSANDAR · 2013 to 2017
$1.8M
NCI NIH HHS R01 CA163849
6 · The paper itself

Abstract

PR domain-containing 14 (

Indexed as

AnimalsDisease Models, AnimalDNA-Binding ProteinsDNA MethylationHematopoietic Stem CellsHumansMiceNeoplastic Stem CellsPluripotent Stem CellsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaRepressor ProteinsRNA-Binding ProteinsTranscription FactorsCbfa2t3 protein, mouseDNA-Binding ProteinsPrdm14 protein, mouseRepressor ProteinsRNA-Binding ProteinsTranscription Factors

Identifiers

PMID31015254
PMCPMC6610658
OpenAlexW2941944767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.