Aminoguanidines: New leads for treatment of Giardia duodenalis infection.

Rebecca J Abraham, Sam Abraham, Andrew J Stevens, Stephen W Page, Adam McCluskey, Darren J Trott, Ryan M O'Handley

Abstract read

In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Synergistic Effect of Polysaccharides from Chamomile Tea with Nitazoxanide Increases Treatment Efficacy againstLife (Basel, Switzerland) · 2022
Article
Antigiardial Activity of Novel Guanidine Compounds.ChemMedChem · 2022
Article
A Review of the Biological Activity of Amidrazone Derivatives.Pharmaceuticals (Basel, Switzerland) · 2022
Review
In Vitro Activity of Robenidine Analogues NCL259 and NCL265 against Gram-Negative Pathogens.Antibiotics (Basel, Switzerland) · 2022
Article
Robenidine Analogues Are Potent Antimalarials in Drug-ResistantACS infectious diseases · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca J AbrahamThe University of Adelaide, School of Animal and Veterinary Science, Roseworthy, South Australia, 5352, Australia; Murdoch University, School of Veterinary and Life Science, Murdoch, Western Australia, 6150, Australia. Electronic address: r.abraham@murdoch.edu.au.

Sam AbrahamMurdoch University, School of Veterinary and Life Science, Murdoch, Western Australia, 6150, Australia.

Andrew J StevensChemistry, School of Environmental and Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Stephen W PageNeoculi Pty Ltd, Burwood, New South Wales, Australia.

Adam McCluskeyChemistry, School of Environmental and Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Darren J TrottThe University of Adelaide, School of Animal and Veterinary Science, Roseworthy, South Australia, 5352, Australia.

Ryan M O'HandleyThe University of Adelaide, School of Animal and Veterinary Science, Roseworthy, South Australia, 5352, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Giardia duodenalis is an ubiquitous parasitic pathogen that causes significant morbidity and mortality worldwide. Failures in drug therapy are commonly due to poor patient compliance as a result of the need for repeated administration, off target drug effects and increasing parasite drug resistance. In this study the in vitro efficacy and selectivity of the aminoguanidine compound robenidine and 2 structural analogues against Giardia were determined. After 5 h exposure to each compound the IC

Indexed as

AnimalsAntiprotozoal AgentsCell MembraneGiardia lambliaGiardiasisGuanidinesHumansParasitic Sensitivity TestsTrophozoitesAntiprotozoal AgentsGuanidinespimagedineAdherenceAntigiardialDrug developmentGiardia duodenalisGiardiasisGiardicidal

Identifiers

PMID31015151

DOI10.1016/j.ijpddr.2019.04.003

PMCPMC6479099

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.