ArticleiScience2019
Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Multicellular PID control for robust regulation of biological processes.Journal of the Royal Society, Interface · 2025Article
- Anti-windup strategies for biomolecular control systems facilitated by model reduction theory for sequestration networks.Science advances · 2024Article
- Noise properties of adaptation-conferring biochemical control modules.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Regulation strategies for two-output biomolecular networks.Journal of the Royal Society, Interface · 2023Article
- A cybergenetic framework for engineering intein-mediated integral feedback control systems.Nature communications · 2023Article
- Frequency spectra and the color of cellular noise.Nature communications · 2022Article
- A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance.Nature communications · 2022Article
- Restoring circadian gene profiles in clock networks using synthetic feedback control.NPJ systems biology and applications · 2022Article
- Biomolecular mechanisms for signal differentiation.iScience · 2021Article
- Rapid prototyping and design of cybergenetic single-cell controllers.Nature communications · 2021Article
- Control strategies to manage trade-offs during microbial production.Current opinion in biotechnology · 2020Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As we begin to design increasingly complex synthetic biomolecular systems, it is essential to develop rational design methodologies that yield predictable circuit performance. Here we apply mathematical tools from the theory of control and dynamical systems to yield practical insights into the architecture and function of a particular class of biological feedback circuit. Specifically, we show that it is possible to analytically characterize both the operating regime and performance tradeoffs of an antithetic integral feedback circuit architecture. Furthermore, we demonstrate how these principles can be applied to inform the design process of a particular synthetic feedback circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.