ArticleToxicon : official journal of the International Society on Toxinology2019
The isolation and characterization of a new snake venom cysteine-rich secretory protein (svCRiSP) from the venom of the Southern Pacific rattlesnake and its effect on vascular permeability.
Article in Toxicon : official journal of the International Society on Toxinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Snake Toxins Affecting Blood Vessel Walls: Mode of Action and Biological Significance.International journal of molecular sciences · 2025Review
- Article
- Exploring the Venom Gland Transcriptome ofToxins · 2024Article
- Identification and Evolutionary Analysis of the Widely Distributed CAP Superfamily in Spider Venom.Toxins · 2024Article
- Article
- Snake Venom Components as Therapeutic Drugs in Ischemic Heart Disease.Biomolecules · 2023Review
- Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced byToxins · 2023Article
- Effect of the snake venom component crotamine on lymphatic endothelial cell responses and lymph transport.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Isolation and short-term culturing of primary lymphatic endothelial cells from collecting lymphatics: A techniques study.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Biochemical and hemostatic description of a thrombin-like enzyme TLBro fromFrontiers in chemistry · 2023Article
- Comparative venomic profiles of three spiders of the genusThe journal of venomous animals and toxins including tropical diseases · 2022Article
- An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells.Frontiers in oncology · 2022Review
- Article
- Snake Venom Components: Tools and Cures to Target Cardiovascular Diseases.Molecules (Basel, Switzerland) · 2021Review
- Proteome Analysis of Toxic Fractions of Iranian Cobra (Naja naja Oxiana) Snake Venom Using Two-Dimensional Electrophoresis and Mass Spectrometry.Archives of Razi Institute · 2021Article
- Biological activities of a new crotamine-like peptide from Crotalus oreganus helleri on C2C12 and CHO cell lines, and ultrastructural changes on motor endplate and striated muscle.Toxicon : official journal of the International Society on Toxinology · 2020Article
- Review
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8 authors.
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Abstract
A novel snake venom cysteine-rich secretory protein (svCRiSP), Hellerin, was purified from C. o. helleri venom using sequential reverse phase and cation-exchange chromatography. Gel electrophoresis, N-terminal sequencing, and LC-MS/MS sequencing identified a single protein with a molecular mass of approximately 24.8 kDa and confirmed its identity as a svCRiSP. Hellerin had cytotoxic effects on human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner but not in human dermal lymphatic endothelial cells (HDLECs) and human dermal blood endothelial cells (HDBECs). Hellerin produced a dramatic increase in both blood vascular permeability in vivo, and in the trans-epithelial permeability of cultured HDLEC and HDBEC cells. This is the first study that describes the effect of a svCRiSP on vascular, blood and lymphatic permeability.
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