Evidence map›Paper›PMID 31014927›Full record

ArticleMolecular metabolism2019

G

Min Chen, Eric A Wilson, Zhenzhong Cui, Hui Sun, Yogendra B Shrestha, Brandon Podyma, Christina H Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. International journal of molecular sciences · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Hypothalamic control of energy expenditure and thermogenesis.Experimental & molecular medicine · 2022
    Review
  12. GAmerican journal of physiology. Endocrinology and metabolism · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Min ChenMetabolic Diseases Branch, Bethesda, MD, 20892, USA. Electronic address: minc@niddk.nih.gov.
Eric A WilsonMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Zhenzhong CuiMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Hui SunMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Yogendra B ShresthaMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Brandon PodymaMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Christina H LeMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Benedetta NaglieriMetabolic Diseases Branch, Bethesda, MD, 20892, USA.
Karel PacakSection on Medical Neuroendocrinology, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Oksana GavrilovaMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Lee S WeinsteinMetabolic Diseases Branch, Bethesda, MD, 20892, USA. Electronic address: leew@mail.nih.gov.
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Role of Gs-alpha in central regulation of energy and glucose metabolismZIADK043315 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WEINSTEIN, LEE · 2009 to 2025
$9.0M
Role of the Gnas Gene in Metabolic RegulationZIADK043313 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WEINSTEIN, LEE · 2009 to 2025
$4.9M
6 · The paper itself

Abstract

objectiveG

methodsWe created mice (DMHGsKO) with G

resultsDMHGsKO mice developed severe, early-onset obesity associated with hyperphagia and reduced energy expenditure and locomotor activity, along with impaired brown adipose tissue thermogenesis. Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/G

conclusionsDMH G

Indexed as

Adipose Tissue, BrownAnimalsEnergy MetabolismGene Expression RegulationGenetic Predisposition to DiseaseGlucoseGTP-Binding Protein alpha Subunits, GsHomeostasisHyperphagiaHypothalamusLeptinMaleMiceMice, KnockoutObesityProtein Tyrosine Phosphatase, Non-Receptor Type 1GlucoseGTP-Binding Protein alpha Subunits, GsLeptinMC4R protein, mouseProtein Tyrosine Phosphatase, Non-Receptor Type 1Ptpn1 protein, mouseReceptor, Melanocortin, Type 4G proteinHypothalamusObesitySympathetic nervous systemThermogenesis

Identifiers

PMID31014927
PMCPMC6601467
OpenAlexW2939831608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.