ArticleRespiratory research2019
The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Ventilatory Threshold and Risk of Pulmonary Exacerbations in Cystic Fibrosis.Respiratory care · 2023Article
- Association of air pollution exposure with exercise-induced oxygen desaturation in COPD.Respiratory research · 2022Article
- Ventilatory efficiency and its clinical and prognostic value in adults with cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Identification of Subclinical Lung Involvement in ACPA-Positive Subjects through Functional Assessment and Serum Biomarkers.International journal of molecular sciences · 2020Article
- Decreased ventilatory efficiency during incremental exercise in bronchiectasis.Journal of thoracic disease · 2020Article
- Exercise and Cystic Fibrosis.Advances in experimental medicine and biology · 2020Review
- Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance. High-resolution computed tomography (HRCT) of the lung can detect pulmonary abnormalities in CF patients. We aimed to identify the determinants of exercise ventilatory inefficiency and DH using HRCT-derived metrics.
methodsFifty-two adult CF patients were prospectively enrolled; all participants underwent cardio-pulmonary exercise test (CPET) and HRCT. Radiological impairment was evaluated by the Brody II scoring system. Slope and intercept of the minute ventilation/CO
resultsFour groups of patients were identified based on the combination of ventilatory efficiency (Vef) or inefficiency (Vin) and the presence/absence of DH. Compared to other groups, CF adults with Vin and DH had worse functional status and higher total (T), bronchiectasis (B) and air trapping (AT) scores at HRCT. Significant correlations were found between V'
conclusionIn adult CF cohort, values of HRCT metrics are determinants of Vin (AT) and DH (T, B, AWT, MP).
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